LY6E

Protein-coding gene in the species Homo sapiens

LY6E
Identifiers
AliasesLY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDsOMIM: 601384; MGI: 106651; HomoloGene: 56411; GeneCards: LY6E; OMA:LY6E - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for LY6E
Genomic location for LY6E
Band8q24.3Start143,017,982 bp[1]
End143,023,832 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for LY6E
Genomic location for LY6E
Band15 D3|15 34.29 cMStart74,826,900 bp[2]
End74,831,754 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • granulocyte

  • olfactory zone of nasal mucosa

  • stromal cell of endometrium

  • placenta

  • right ovary

  • right lung

  • upper lobe of left lung

  • right frontal lobe

  • hippocampus proper
Top expressed in
  • lactiferous gland

  • superior surface of tongue

  • gallbladder

  • corneal stroma

  • cardiac muscles

  • cardiac muscle tissue of left ventricle

  • CA3 field

  • right kidney

  • perirhinal cortex

  • esophagus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • acetylcholine receptor inhibitor activity
Cellular component
  • integral component of plasma membrane
  • membrane
  • anchored component of membrane
  • extracellular region
  • plasma membrane
Biological process
  • cell surface receptor signaling pathway
  • negative regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4061

17069

Ensembl

ENSG00000278032
ENSG00000160932

ENSMUSG00000022587

UniProt

Q16553

Q64253

RefSeq (mRNA)

NM_002346
NM_001127213

NM_001164036
NM_001164037
NM_001164038
NM_001164039
NM_001164040

NM_008529
NM_001374138

RefSeq (protein)

NP_001120685
NP_002337

NP_001157508
NP_001157509
NP_001157510
NP_001157511
NP_001157512

NP_032555
NP_001361067

Location (UCSC)Chr 8: 143.02 – 143.02 MbChr 15: 74.83 – 74.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[9] Further research is required to validate Ly6E for translation research. [1]

References

  1. ^ a b c ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022587 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. doi:10.4049/jimmunol.157.3.969. PMID 8757598.
  6. ^ Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. Bibcode:1996PNAS...93.5910M. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
  7. ^ "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
  8. ^ Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
  9. ^ Hossiny MA, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB (1997). "A gain of novel tissue specificity in the human Ly-6 gene E48". J. Immunol. 159 (10): 4879–86. doi:10.4049/jimmunol.159.10.4879. PMID 9366413.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG (1998). "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1". J. Immunol. 160 (1): 197–208. doi:10.4049/jimmunol.160.1.197. PMID 9551972.
  • Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T (1998). "Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex". J. Biol. Chem. 273 (20): 12301–6. doi:10.1074/jbc.273.20.12301. PMID 9575182.
  • Ding L, Shevach EM (2001). "Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen". Immunology. 104 (1): 28–36. doi:10.1046/j.1365-2567.2001.01275.x. PMC 1783287. PMID 11576217.
  • Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ (2002). "Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland". Mol. Cell. Biol. 22 (3): 946–52. doi:10.1128/MCB.22.3.946-952.2002. PMC 133557. PMID 11784869.
  • de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH (2003). "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma". Int. J. Cancer. 103 (6): 768–74. doi:10.1002/ijc.10903. PMID 12516096. S2CID 42182637.


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