MAF1

Protein-coding gene in the species Homo sapiens
MAF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3NR5

Identifiers
AliasesMAF1, MAF1 homolog, negative regulator of RNA polymerase III
External IDsOMIM: 610210; MGI: 1916127; HomoloGene: 49867; GeneCards: MAF1; OMA:MAF1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MAF1
Genomic location for MAF1
Band8q24.3Start144,104,461 bp[1]
End144,107,611 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for MAF1
Genomic location for MAF1
Band15|15 D3Start76,235,494 bp[2]
End76,238,580 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • apex of heart

  • muscle layer of sigmoid colon

  • popliteal artery

  • tibial arteries

  • right coronary artery

  • gastric mucosa

  • left ventricle

  • left coronary artery
Top expressed in
  • medial ganglionic eminence

  • Rostral migratory stream

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • muscle of thigh

  • right kidney

  • thymus

  • granulocyte

  • ventricular zone

  • blood
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA polymerase III core binding
  • GABA receptor binding
  • protein binding
Cellular component
  • cytoplasm
  • intracellular membrane-bounded organelle
  • plasma membrane
  • inhibitory synapse
  • intracellular anatomical structure
  • axon
  • dendrite
  • nucleolus
  • perinuclear region of cytoplasm
  • nucleus
  • nucleoplasm
  • cytosol
  • centrosome
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase III
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84232

68877

Ensembl

ENSG00000179632

ENSMUSG00000022553

UniProt

Q9H063

Q9D0U6

RefSeq (mRNA)

NM_032272

NM_001164607
NM_001164608
NM_026859

RefSeq (protein)

NP_115648

NP_001158079
NP_001158080
NP_081135

Location (UCSC)Chr 8: 144.1 – 144.11 MbChr 15: 76.24 – 76.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.[5][6][7]

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179632 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022553 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, Hopper AK, Sentenac A, Boguta M (Jul 2001). "Maf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae". Mol Cell Biol. 21 (15): 5031–40. doi:10.1128/MCB.21.15.5031-5040.2001. PMC 87229. PMID 11438659.
  7. ^ a b "Entrez Gene: MAF1 MAF1 homolog (S. cerevisiae)".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Upadhya R, Lee J, Willis IM (2003). "Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription". Mol. Cell. 10 (6): 1489–94. doi:10.1016/S1097-2765(02)00787-6. PMID 12504022.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.
  • Rollins J, Veras I, Cabarcas S, et al. (2007). "Human Maf1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf1 and Brf2". Int. J. Biol. Sci. 3 (5): 292–302. doi:10.7150/ijbs.3.292. PMC 1865091. PMID 17505538.


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