MCF2L

Gene found in humans

MCF2L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1KZ7, 1KZG, 1LB1, 1RJ2

Identifiers
AliasesMCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
External IDsOMIM: 609499; MGI: 103263; HomoloGene: 11804; GeneCards: MCF2L; OMA:MCF2L - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for MCF2L
Genomic location for MCF2L
Band13q34Start112,894,378 bp[1]
End113,099,742 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for MCF2L
Genomic location for MCF2L
Band8|8 A1.1Start12,873,806 bp[2]
End13,020,905 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • paraflocculus of cerebellum

  • pituitary gland

  • apex of heart

  • anterior pituitary

  • C1 segment

  • Brodmann area 9

  • prefrontal cortex

  • primary visual cortex
Top expressed in
  • olfactory epithelium

  • neural layer of retina

  • cerebellar cortex

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • pituitary gland

  • lobe of cerebellum

  • cerebellar vermis

  • islet of Langerhans
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol binding
  • lipid binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • extrinsic component of cytoplasmic side of plasma membrane
  • cytosol
  • plasma membrane
  • membrane
  • endomembrane system
  • extracellular space
Biological process
  • positive regulation of Rho protein signal transduction
  • regulation of Rho protein signal transduction
  • intracellular signal transduction
  • regulation of small GTPase mediated signal transduction
  • positive regulation of apoptotic process
  • G protein-coupled receptor signaling pathway
  • regulation of molecular function
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23263

17207

Ensembl

ENSG00000126217

ENSMUSG00000031442

UniProt

O15068

Q64096

RefSeq (mRNA)
NM_001112732
NM_024979
NM_001320815
NM_001320816
NM_001320817

NM_001366644
NM_001366645
NM_001366646

NM_001159485
NM_001159486
NM_178076

RefSeq (protein)
NP_001106203
NP_001307744
NP_001307745
NP_001307746
NP_079255

NP_001353573
NP_001353574
NP_001353575

n/a

Location (UCSC)Chr 13: 112.89 – 113.1 MbChr 8: 12.87 – 13.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126217 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031442 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. ^ "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".

Further reading

  • Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T (Oct 1994). "A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20): 4776–86. doi:10.1002/j.1460-2075.1994.tb06803.x. PMC 395416. PMID 7957046.
  • Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (Mar 2002). "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange". The EMBO Journal. 21 (6): 1315–26. doi:10.1093/emboj/21.6.1315. PMC 125919. PMID 11889037.
  • Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
  • Yamauchi J, Hirasawa A, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y, Tsujimoto G, Itoh H (Aug 2002). "Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase". Biochemical and Biophysical Research Communications. 296 (1): 85–92. doi:10.1016/S0006-291X(02)00839-2. PMID 12147231.
  • Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
  • Cheng L, Mahon GM, Kostenko EV, Whitehead IP (Mar 2004). "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal of Biological Chemistry. 279 (13): 12786–93. doi:10.1074/jbc.M313099200. PMID 14701795.
  • Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites" (PDF). Cellular Signalling. 16 (8): 899–906. doi:10.1016/j.cellsig.2004.01.007. hdl:20.500.14094/D1002967. PMID 15157669. Archived from the original (PDF) on 2020-07-21. Retrieved 2020-07-21.
  • Kostenko EV, Mahon GM, Cheng L, Whitehead IP (Jan 2005). "The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs". The Journal of Biological Chemistry. 280 (4): 2807–17. doi:10.1074/jbc.M411139200. PMID 15531584.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1". The Journal of Biological Chemistry. 282 (32): 23296–305. doi:10.1074/jbc.M700950200. hdl:20.500.14094/D1004143. PMID 17562712.
  • v
  • t
  • e
  • 1kz7: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
    1kz7: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
  • 1kzg: DbsCdc42(Y889F)
    1kzg: DbsCdc42(Y889F)
  • 1lb1: Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
    1lb1: Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
  • 1rj2: Crystal structure of the DH/PH fragment of Dbs without bound GTPase
    1rj2: Crystal structure of the DH/PH fragment of Dbs without bound GTPase


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