MEAF6

Protein-coding gene in the species Homo sapiens
MEAF6
Identifiers
AliasesMEAF6, C1orf149, CENP-28, EAF6, NY-SAR-91, MYST/Esa1 associated factor 6
External IDsOMIM: 611001; MGI: 1917338; HomoloGene: 11240; GeneCards: MEAF6; OMA:MEAF6 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MEAF6
Genomic location for MEAF6
Band1p34.3Start37,489,993 bp[1]
End37,514,766 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for MEAF6
Genomic location for MEAF6
Band4|4 D2.2Start124,978,927 bp[2]
End125,007,031 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • ganglionic eminence

  • Achilles tendon

  • anterior pituitary

  • pons

  • secondary oocyte

  • islet of Langerhans

  • seminal vesicula

  • prefrontal cortex

  • bronchial epithelial cell
Top expressed in
  • superior cervical ganglion

  • neural layer of retina

  • genital tubercle

  • tail of embryo

  • superior frontal gyrus

  • ventricular zone

  • hand

  • neural tube

  • zygote

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • histone acetyltransferase activity (H3-K23 specific)
Cellular component
  • NuA4 histone acetyltransferase complex
  • MOZ/MORF histone acetyltransferase complex
  • histone acetyltransferase complex
  • nucleus
  • nucleolus
  • chromosome
  • kinetochore
  • chromosome, centromeric region
  • nucleoplasm
  • NuA3a histone acetyltransferase complex
  • NuA3b histone acetyltransferase complex
Biological process
  • histone H4-K12 acetylation
  • regulation of transcription, DNA-templated
  • histone H4-K5 acetylation
  • histone acetylation
  • histone H4-K8 acetylation
  • histone H4-K16 acetylation
  • histone H3-K14 acetylation
  • histone H2A acetylation
  • transcription, DNA-templated
  • regulation of signal transduction by p53 class mediator
  • chromatin organization
  • histone H3-K23 acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64769

70088

Ensembl

ENSG00000163875

ENSMUSG00000028863

UniProt

Q9HAF1

Q2VPQ9

RefSeq (mRNA)

NM_001270875
NM_001270876
NM_022756

NM_001290701
NM_027310
NM_001374123

RefSeq (protein)

NP_001257804
NP_001257805
NP_073593

NP_001277630
NP_081586
NP_001361052

Location (UCSC)Chr 1: 37.49 – 37.51 MbChr 4: 124.98 – 125.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.[5][6][7][8][9][10]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163875 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028863 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
  8. ^ Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
  9. ^ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
  10. ^ "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. Bibcode:2003PNAS..100.2651L. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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