MED10

Protein-coding gene in the species Homo sapiens
MED10
Identifiers
AliasesMED10, NUT2, TRG20, L6, mediator complex subunit 10
External IDsOMIM: 612382; MGI: 106331; HomoloGene: 44533; GeneCards: MED10; OMA:MED10 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MED10
Genomic location for MED10
Band5p15.31Start6,371,874 bp[1]
End6,378,571 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for MED10
Genomic location for MED10
Band13 C1|13 35.55 cMStart69,950,514 bp[2]
End69,964,223 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • Brodmann area 9

  • muscle layer of sigmoid colon

  • prefrontal cortex

  • tibial arteries

  • oocyte

  • cingulate gyrus

  • anterior cingulate cortex

  • C1 segment

  • thoracic aorta
Top expressed in
  • seminiferous tubule

  • morula

  • morula

  • facial motor nucleus

  • neural tube

  • ovary

  • gastrula

  • zygote

  • medial ganglionic eminence

  • otic placode
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • ubiquitin protein ligase activity
  • transcription coregulator activity
Cellular component
  • nucleoplasm
  • mediator complex
  • ubiquitin ligase complex
  • nucleus
  • core mediator complex
Biological process
  • positive regulation of transcription by RNA polymerase II
  • protein ubiquitination
  • transcription initiation from RNA polymerase II promoter
  • stem cell population maintenance
  • regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84246

28077

Ensembl

ENSG00000133398

ENSMUSG00000021598

UniProt

Q9BTT4

Q9CXU0

RefSeq (mRNA)

NM_032286

NM_138596
NM_001378925

RefSeq (protein)

NP_115662

NP_613062
NP_001365854

Location (UCSC)Chr 5: 6.37 – 6.38 MbChr 13: 69.95 – 69.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.[5]

Function

Med10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.[6][supplied by OMIM, Oct 2008].

See also

  • Mediator

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133398 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021598 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mediator complex subunit 10".
  6. ^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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