MED12L

Protein-coding gene in the species Homo sapiens
MED12L
Identifiers
AliasesMED12L, NOPAR, TNRC11L, TRALP, TRALPUSH, mediator complex subunit 12 like, mediator complex subunit 12L, NIZIDS
External IDsOMIM: 611318; MGI: 2139916; HomoloGene: 43143; GeneCards: MED12L; OMA:MED12L - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MED12L
Genomic location for MED12L
Band3q25.1Start151,085,286 bp[1]
End151,437,072 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MED12L
Genomic location for MED12L
Band3|3 DStart58,913,246 bp[2]
End59,226,103 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • testicle

  • secondary oocyte

  • bone marrow cells

  • gonad

  • ventricular zone

  • ganglionic eminence

  • sural nerve

  • prefrontal cortex

  • Achilles tendon
Top expressed in
  • substantia nigra

  • olfactory epithelium

  • motor neuron

  • renal corpuscle

  • epithelium of lens

  • dorsomedial hypothalamic nucleus

  • fossa

  • lumbar subsegment of spinal cord

  • condyle

  • anterior horn of spinal cord
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coactivator activity
  • beta-catenin binding
  • transcription coregulator activity
Cellular component
  • nucleus
  • mediator complex
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116931

329650

Ensembl

ENSG00000144893

ENSMUSG00000056476

UniProt

Q86YW9

Q8BQM9

RefSeq (mRNA)

NM_053002
NM_001393769

NM_177855

RefSeq (protein)

NP_443728

NP_808523

Location (UCSC)Chr 3: 151.09 – 151.44 MbChr 3: 58.91 – 59.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene. [5]

Function

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010].

See also

  • Mediator

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144893 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056476 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mediator complex subunit 12 like". Retrieved 2018-02-06.

Further reading

  • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.