Protein-coding gene in the species Homo sapiens
MED18 |
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Identifiers |
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Aliases | MED18, p28b, mediator complex subunit 18, SRB5 |
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External IDs | OMIM: 612384; MGI: 1914469; HomoloGene: 9756; GeneCards: MED18; OMA:MED18 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1p35.3 | Start | 28,329,002 bp[1] |
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End | 28,335,965 bp[1] |
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Gene location (Mouse) |
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![Chromosome 4 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 D2.3 | Start | 132,186,042 bp[2] |
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End | 132,191,232 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of transverse colon
- islet of Langerhans
- stromal cell of endometrium
- lymph node
- blood
- rectum
- granulocyte
- skeletal muscle tissue
- duodenum
- appendix
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| Top expressed in | - Region I of hippocampus proper
- hand
- maxillary prominence
- mandibular prominence
- globus pallidus
- intercostal muscle
- internal carotid artery
- parotid gland
- external carotid artery
- mesenteric lymph nodes
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transcription coregulator activity
- protein binding
- ubiquitin protein ligase activity
| Cellular component | - core mediator complex
- mediator complex
- nucleus
- ubiquitin ligase complex
| Biological process | - regulation of transcription by RNA polymerase II
- termination of RNA polymerase II transcription
- regulation of transcription, DNA-templated
- transcription, DNA-templated
- protein ubiquitination
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000130772 ENSG00000284944 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 28.33 – 28.34 Mb | Chr 4: 132.19 – 132.19 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.[5]
Function
Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.[6]
See also
References
- ^ a b c ENSG00000284944 GRCh38: Ensembl release 89: ENSG00000130772, ENSG00000284944 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066042 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mediator complex subunit 18".
- ^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.