MED18

Protein-coding gene in the species Homo sapiens
MED18
Identifiers
AliasesMED18, p28b, mediator complex subunit 18, SRB5
External IDsOMIM: 612384; MGI: 1914469; HomoloGene: 9756; GeneCards: MED18; OMA:MED18 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MED18
Genomic location for MED18
Band1p35.3Start28,329,002 bp[1]
End28,335,965 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for MED18
Genomic location for MED18
Band4|4 D2.3Start132,186,042 bp[2]
End132,191,232 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • islet of Langerhans

  • stromal cell of endometrium

  • lymph node

  • blood

  • rectum

  • granulocyte

  • skeletal muscle tissue

  • duodenum

  • appendix
Top expressed in
  • Region I of hippocampus proper

  • hand

  • maxillary prominence

  • mandibular prominence

  • globus pallidus

  • intercostal muscle

  • internal carotid artery

  • parotid gland

  • external carotid artery

  • mesenteric lymph nodes
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coregulator activity
  • protein binding
  • ubiquitin protein ligase activity
Cellular component
  • core mediator complex
  • mediator complex
  • nucleus
  • ubiquitin ligase complex
Biological process
  • regulation of transcription by RNA polymerase II
  • termination of RNA polymerase II transcription
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54797

67219

Ensembl

ENSG00000130772
ENSG00000284944

ENSMUSG00000066042

UniProt

Q9BUE0

Q9CZ82

RefSeq (mRNA)

NM_001127350
NM_017638

NM_026039

RefSeq (protein)

NP_001120822
NP_060108

NP_080315

Location (UCSC)Chr 1: 28.33 – 28.34 MbChr 4: 132.19 – 132.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.[5]

Function

Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.[6]

See also

  • Mediator

References

  1. ^ a b c ENSG00000284944 GRCh38: Ensembl release 89: ENSG00000130772, ENSG00000284944 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066042 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mediator complex subunit 18".
  6. ^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.