MIR4640 |
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Identifiers |
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Aliases | MIR4640, microRNA 4640 |
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External IDs | GeneCards: MIR4640; OMA:MIR4640 - orthologs |
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Gene location (Human) |
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![Chromosome 6 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png) | Chr. | Chromosome 6 (human)[1] |
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| Band | 6p21.33 | Start | 30,890,883 bp[1] |
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End | 30,890,972 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gastrocnemius muscle
- putamen
- Brodmann area 9
- left coronary artery
- Descending thoracic aorta
- left ventricle
- smooth muscle tissue
- body of stomach
- human kidney
- hippocampus proper
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| | More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 30.89 – 30.89 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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MicroRNA 4640 is a non-coding RNA in humans that is encoded by the MIR4640 gene. [3]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000284370 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MicroRNA 4640". Retrieved 2013-06-27.
Further reading