MMS19

Protein-coding gene in the species Homo sapiens
MMS19
Identifiers
AliasesMMS19, MET18, MMS19L, hMMS19 homolog, cytosolic iron-sulfur assembly component, CIAO4
External IDsOMIM: 614777; MGI: 1919449; HomoloGene: 41480; GeneCards: MMS19; OMA:MMS19 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for MMS19
Genomic location for MMS19
Band10q24.1Start97,458,324 bp[1]
End97,498,794 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for MMS19
Genomic location for MMS19
Band19|19 C3Start41,929,525 bp[2]
End41,969,596 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • anterior pituitary

  • skin of leg

  • right testis

  • skin of abdomen

  • left testis

  • tibial nerve

  • apex of heart

  • right ovary

  • ventricular zone
Top expressed in
  • tail of embryo

  • neural layer of retina

  • genital tubercle

  • muscle of thigh

  • granulocyte

  • ventricular zone

  • superior frontal gyrus

  • thymus

  • lip

  • oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein-macromolecule adaptor activity
  • transcription coactivator activity
  • protein binding
  • enzyme binding
  • signaling receptor complex adaptor activity
  • estrogen receptor binding
Cellular component
  • membrane
  • nucleoplasm
  • transcription factor TFIIH holo complex
  • CIA complex
  • cytoskeleton
  • MMXD complex
  • nucleus
  • cytoplasm
  • spindle
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • chromosome segregation
  • DNA metabolic process
  • cellular response to DNA damage stimulus
  • positive regulation of transcription, DNA-templated
  • iron-sulfur cluster assembly
  • phosphorelay signal transduction system
  • response to hormone
  • DNA repair
  • nucleotide-excision repair
  • transcription, DNA-templated
  • protein maturation by iron-sulfur cluster transfer
  • positive regulation of double-strand break repair via homologous recombination
  • positive regulation of signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64210

72199

Ensembl

ENSG00000155229

ENSMUSG00000025159

UniProt

Q96T76

Q9D071

RefSeq (mRNA)
NM_001289403
NM_001289404
NM_001289405
NM_022362
NM_001330128

NM_001351356
NM_001351357
NM_001351358
NM_001351359

NM_028152
NM_001373946

RefSeq (protein)
NP_001276332
NP_001276333
NP_001276334
NP_001317057
NP_071757

NP_001338285
NP_001338286
NP_001338287
NP_001338288

NP_082428
NP_001360875

Location (UCSC)Chr 10: 97.46 – 97.5 MbChr 19: 41.93 – 41.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155229 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025159 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res. 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC 113875. PMID 11071939.
  6. ^ "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wu X, Li H, Chen JD (2001). "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor". J. Biol. Chem. 276 (26): 23962–8. doi:10.1074/jbc.M101041200. PMID 11279242.
  • Queimado L, Rao M, Schultz RA, et al. (2002). "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant". Nucleic Acids Res. 29 (9): 1884–91. doi:10.1093/nar/29.9.1884. PMC 37259. PMID 11328871.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hatfield MD, Reis AM, Obeso D, et al. (2006). "Identification of MMS19 domains with distinct functions in NER and transcription". DNA Repair (Amst.). 5 (8): 914–24. doi:10.1016/j.dnarep.2006.05.007. PMID 16797255.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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