Protein-coding gene in the species Homo sapiens
MOGAT3 |
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Identifiers |
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Aliases | MOGAT3, DC7, DGAT2L7, MGAT3, DGAT2L2, monoacylglycerol O-acyltransferase 3 |
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External IDs | OMIM: 610184; HomoloGene: 80517; GeneCards: MOGAT3; OMA:MOGAT3 - orthologs |
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Gene location (Human) |
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![Chromosome 7 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png) | Chr. | Chromosome 7 (human)[1] |
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| Band | 7q22.1 | Start | 101,195,007 bp[1] |
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End | 101,201,038 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of transverse colon
- mucosa of ileum
- rectum
- right lobe of liver
- duodenum
- testicle
- jejunal mucosa
- mucosa of sigmoid colon
- appendix
- epithelium of colon
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| | More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - acyltransferase activity
- acyltransferase activity, transferring groups other than amino-acyl groups
- transferase activity
- diacylglycerol O-acyltransferase activity
- 2-acylglycerol O-acyltransferase activity
| Cellular component | - membrane
- integral component of membrane
- endoplasmic reticulum
- endoplasmic reticulum membrane
| Biological process | - lipid metabolism
- glycerol metabolic process
- triglyceride biosynthetic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 7: 101.2 – 101.2 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Monoacylglycerol O-acyltransferase 3 is a protein that in humans is encoded by the MOGAT3 gene.[3]
Function
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.[4]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106384 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Monoacylglycerol O-acyltransferase 3".
- ^ Cheng D, Nelson TC, Chen J, Walker SG, Wardwell-Swanson J, Meegalla R, Taub R, Billheimer JT, Ramaker M, Feder JN (Apr 2003). "Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption". The Journal of Biological Chemistry. 278 (16): 13611–4. doi:10.1074/jbc.C300042200. PMID 12618427.
Further reading
- Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (2003). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.