MOGAT3

Protein-coding gene in the species Homo sapiens
MOGAT3
Identifiers
AliasesMOGAT3, DC7, DGAT2L7, MGAT3, DGAT2L2, monoacylglycerol O-acyltransferase 3
External IDsOMIM: 610184; HomoloGene: 80517; GeneCards: MOGAT3; OMA:MOGAT3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MOGAT3
Genomic location for MOGAT3
Band7q22.1Start101,195,007 bp[1]
End101,201,038 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • mucosa of ileum

  • rectum

  • right lobe of liver

  • duodenum

  • testicle

  • jejunal mucosa

  • mucosa of sigmoid colon

  • appendix

  • epithelium of colon
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • acyltransferase activity
  • acyltransferase activity, transferring groups other than amino-acyl groups
  • transferase activity
  • diacylglycerol O-acyltransferase activity
  • 2-acylglycerol O-acyltransferase activity
Cellular component
  • membrane
  • integral component of membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
Biological process
  • lipid metabolism
  • glycerol metabolic process
  • triglyceride biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

346606

n/a

Ensembl

ENSG00000106384

n/a

UniProt

Q86VF5

n/a

RefSeq (mRNA)

NM_001287147
NM_178176

n/a

RefSeq (protein)

NP_001274076
NP_835470

n/a

Location (UCSC)Chr 7: 101.2 – 101.2 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Monoacylglycerol O-acyltransferase 3 is a protein that in humans is encoded by the MOGAT3 gene.[3]

Function

Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106384 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Monoacylglycerol O-acyltransferase 3".
  4. ^ Cheng D, Nelson TC, Chen J, Walker SG, Wardwell-Swanson J, Meegalla R, Taub R, Billheimer JT, Ramaker M, Feder JN (Apr 2003). "Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption". The Journal of Biological Chemistry. 278 (16): 13611–4. doi:10.1074/jbc.C300042200. PMID 12618427.

Further reading

  • Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (2003). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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