MRPL55

Protein-coding gene in the species Homo sapiens
MRPL55
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J9M

Identifiers
AliasesMRPL55, AAVG5835, L55nt, MRP-L55, PRO19675, mitochondrial ribosomal protein L55
External IDsOMIM: 611859; MGI: 1914462; HomoloGene: 12098; GeneCards: MRPL55; OMA:MRPL55 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MRPL55
Genomic location for MRPL55
Band1q42.13Start228,106,679 bp[1]
End228,109,312 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MRPL55
Genomic location for MRPL55
Band11|11 B1.3Start59,093,312 bp[2]
End59,096,960 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • prefrontal cortex

  • right lobe of liver

  • Brodmann area 9

  • anterior cingulate cortex

  • olfactory zone of nasal mucosa

  • muscle of thigh

  • anterior pituitary

  • right adrenal gland

  • left adrenal cortex
Top expressed in
  • right ventricle

  • digastric muscle

  • right kidney

  • temporal muscle

  • sternocleidomastoid muscle

  • yolk sac

  • myocardium of ventricle

  • blastocyst

  • morula

  • cardiac muscle tissue of left ventricle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
Cellular component
  • ribosome
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial large ribosomal subunit
Biological process
  • mitochondrial translational elongation
  • protein biosynthesis
  • mitochondrial translational termination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

128308

67212

Ensembl

ENSG00000162910

ENSMUSG00000036860

UniProt

Q7Z7F7

Q9CZ83

RefSeq (mRNA)
NM_181441
NM_181454
NM_181455
NM_181456
NM_181462

NM_181463
NM_181464
NM_181465
NM_001321284

NM_001302334
NM_001302335
NM_001302336
NM_026035
NM_001362908

NM_001362909

RefSeq (protein)
NP_001308213
NP_852106
NP_852119
NP_852120
NP_852121

NP_852127
NP_852128
NP_852129
NP_852130

NP_001289263
NP_001289264
NP_001289265
NP_080311
NP_001349837

NP_001349838

Location (UCSC)Chr 1: 228.11 – 228.11 MbChr 11: 59.09 – 59.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L55, mitochondrial is a protein that in humans is encoded by the MRPL55 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162910 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036860 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL55 mitochondrial ribosomal protein L55".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–43969. doi:10.1074/jbc.M106510200. PMID 11551941.
  • O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–79. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–480. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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