MRPS18A

Protein-coding gene in the species Homo sapiens
MRPS18A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J7Y, 3J9M

Identifiers
AliasesMRPS18A, HumanS18b, MRP-S18-3, MRPS18-3, S18bmt, mitochondrial ribosomal protein S18A, S18mt-a, MRP-S18-a
External IDsOMIM: 611981; MGI: 1915815; HomoloGene: 32391; GeneCards: MRPS18A; OMA:MRPS18A - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MRPS18A
Genomic location for MRPS18A
Band6p21.1Start43,671,202 bp[1]
End43,687,791 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for MRPS18A
Genomic location for MRPS18A
Band17|17 CStart46,421,912 bp[2]
End46,439,836 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • muscle of thigh

  • mucosa of transverse colon

  • apex of heart

  • body of stomach

  • rectum

  • left ventricle

  • endothelial cell

  • right adrenal gland

  • right lobe of liver
Top expressed in
  • seminal vesicula

  • yolk sac

  • right kidney

  • interventricular septum

  • soleus muscle

  • right ventricle

  • intercostal muscle

  • digastric muscle

  • muscle of thigh

  • temporal muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • structural constituent of ribosome
  • small ribosomal subunit rRNA binding
Cellular component
  • mitochondrial inner membrane
  • ribosome
  • intracellular anatomical structure
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • cytosolic small ribosomal subunit
  • mitochondrial large ribosomal subunit
Biological process
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • protein biosynthesis
  • mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55168

68565

Ensembl

ENSG00000096080

ENSMUSG00000023967

UniProt

Q9NVS2

Q99N85

RefSeq (mRNA)

NM_001193343
NM_018135

NM_026768

RefSeq (protein)

NP_001180272
NP_060605

NP_081044

Location (UCSC)Chr 6: 43.67 – 43.69 MbChr 17: 46.42 – 46.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S18a, mitochondrial is a protein that in humans is encoded by the MRPS18A gene.[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096080 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023967 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  7. ^ a b "Entrez Gene: MRPS18A mitochondrial ribosomal protein S18A".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.


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