MTPN

A MPTN Is an protein coding gene in the following species: "Homo sapiens".

MTPN

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3AAA

Identifiers

Aliases

MTPN, GCDP, V-1, myotrophin

External IDs

OMIM: 606484; MGI: 99445; HomoloGene: 40607; GeneCards: MTPN; OMA:MTPN - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q33	Start	135,926,760 bp^[1]
Band	7q33	End	135,977,359 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 B1	Start	35,485,841 bp^[2]
Band	6\|6 B1	End	35,516,823 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cardiac muscle tissue of right atrium

skin of arm

mucosa of ileum

myocardium of left ventricle

superficial temporal artery

monocyte

lower lobe of lung

trabecular bone

Brodmann area 46

tibialis anterior muscle

Top expressed in

retinal pigment epithelium

Rostral migratory stream

barrel cortex

ciliary body

epithelium of lens

dorsal striatum

endothelial cell of lymphatic vessel

subiculum

prefrontal cortex

pineal gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	sequence-specific DNA binding
Cellular component	cytoplasm F-actin capping protein complex axon perinuclear region of cytoplasm nucleus cytosol
Biological process	regulation of striated muscle tissue development catecholamine metabolic process positive regulation of cardiac muscle hypertrophy regulation of barbed-end actin filament capping cellular response to mechanical stimulus skeletal muscle tissue regeneration neuron differentiation striated muscle cell differentiation regulation of translation cerebellar granule cell differentiation positive regulation of NF-kappaB transcription factor activity positive regulation of cell growth positive regulation of macromolecule biosynthetic process regulation of cell size
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


136319


14489

Ensembl


ENSG00000105887


ENSMUSG00000029840

UniProt


P58546


P62774

RefSeq (mRNA)


NM_145808


NM_008098

RefSeq (protein)


NP_665807


NP_032124

Location (UCSC)

Chr 7: 135.93 – 135.98 Mb

Chr 6: 35.49 – 35.52 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene.^[5]^[6]

Interactions

MTPN has been shown to interact with RELA^[7] and REL.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205. S2CID 30646120.
^ "Entrez Gene: MTPN myotrophin".
^ ^a ^b Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26). United States: 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

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Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi:10.1161/01.res.73.1.98. PMID 8508536.
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