MTSS1

Protein-coding gene in the species Homo sapiens
MTSS1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D1K

Identifiers
AliasesMTSS1, MIM, MIMA, MIMB, metastasis suppressor 1, I-BAR domain containing, MTSS I-BAR domain containing 1
External IDsOMIM: 608486; MGI: 2384818; HomoloGene: 8841; GeneCards: MTSS1; OMA:MTSS1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MTSS1
Genomic location for MTSS1
Band8q24.13Start124,550,784 bp[1]
End124,728,473 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for MTSS1
Genomic location for MTSS1
Band15|15 D1Start58,813,083 bp[2]
End58,953,854 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • glomerulus

  • metanephric glomerulus

  • hair follicle

  • subthalamic nucleus

  • renal medulla

  • skin of hip

  • inferior ganglion of vagus nerve

  • skin of thigh

  • bronchial epithelial cell
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • Rostral migratory stream

  • vestibular membrane of cochlear duct

  • stroma of bone marrow

  • zygote

  • habenula

  • secondary oocyte

  • pineal gland

  • iris
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • actin monomer binding
  • protein binding
  • identical protein binding
  • actin binding
  • signaling receptor binding
Cellular component
  • cytoplasm
  • ruffle
  • endocytic vesicle
  • actin cytoskeleton
  • cytoskeleton
Biological process
  • renal tubule morphogenesis
  • nephron tubule epithelial cell differentiation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • cellular response to fluid shear stress
  • cell adhesion
  • epithelial cell proliferation involved in renal tubule morphogenesis
  • microspike assembly
  • negative regulation of epithelial cell proliferation
  • plasma membrane organization
  • actin cytoskeleton organization
  • glomerulus morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9788

211401

Ensembl

ENSG00000170873

ENSMUSG00000022353

UniProt

O43312

Q8R1S4

RefSeq (mRNA)
NM_001282971
NM_001282974
NM_014751
NM_001363294
NM_001363295

NM_001363296
NM_001363297
NM_001363298
NM_001363299
NM_001363300
NM_001363301
NM_001363302

NM_001146180
NM_144800

RefSeq (protein)
NP_001269900
NP_001269903
NP_055566
NP_001350223
NP_001350224

NP_001350225
NP_001350226
NP_001350227
NP_001350228
NP_001350229
NP_001350230
NP_001350231

NP_001139652
NP_659049
NP_001390427
NP_001390428
NP_001390429

NP_001390430
NP_001390431
NP_001390432
NP_001390433
NP_001390434
NP_001390435
NP_001390436

Location (UCSC)Chr 8: 124.55 – 124.73 MbChr 15: 58.81 – 58.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.[5][6][7] True to its name, it codes for a metastasis suppressor.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170873 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022353 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi:10.1074/jbc.M212113200. PMID 12482861.
  6. ^ Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703. PMID 12082544.
  7. ^ "Entrez Gene: MTSS1 metastasis suppressor 1".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC 1223315. PMID 12570871.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi:10.1074/jbc.M309408200. PMID 14752106.
  • Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
  • Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID 15488640.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMC 528890. PMID 15545630.
  • Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMC 2171717. PMID 15684034.
  • Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell Sci. 118 (Pt 22): 5393–403. doi:10.1242/jcs.02640. PMID 16280553.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation". Int. J. Cancer. 119 (10): 2287–93. doi:10.1002/ijc.22106. PMID 16921485. S2CID 6700103.
  • Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID 17442377.
  • v
  • t
  • e
  • 2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I
    2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I
  • 2d1l: Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)
    2d1l: Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)


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