Mitoguardin 1

Protein-coding gene in the species Homo sapiens
MIGA1
Identifiers
AliasesMIGA1, FAM73A, family with sequence similarity 73 member A, mitoguardin 1
External IDsOMIM: 616773; MGI: 1924567; HomoloGene: 18369; GeneCards: MIGA1; OMA:MIGA1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MIGA1
Genomic location for MIGA1
Band1p31.1Start77,779,624 bp[1]
End77,879,539 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MIGA1
Genomic location for MIGA1
Band3|3 H3Start151,979,486 bp[2]
End152,046,044 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Pars compacta

  • Brodmann area 23

  • pars reticulata

  • lateral nuclear group of thalamus

  • pancreatic epithelial cell

  • pons

  • subthalamic nucleus

  • inferior ganglion of vagus nerve

  • external globus pallidus
Top expressed in
  • dorsomedial hypothalamic nucleus

  • ventral tegmental area

  • pontine nuclei

  • dorsal tegmental nucleus

  • lateral hypothalamus

  • medial vestibular nucleus

  • mammillary body

  • piriform cortex

  • superior colliculus

  • medial dorsal nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
  • protein heterodimerization activity
Cellular component
  • mitochondrial outer membrane
  • integral component of membrane
  • mitochondrion
  • membrane
  • integral component of plasma membrane
Biological process
  • mitochondrial fusion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

374986

215708

Ensembl

ENSG00000180488

ENSMUSG00000054942

UniProt

Q8NAN2

Q4QQM5

RefSeq (mRNA)

NM_001270384
NM_198549
NM_001363583
NM_001363584
NM_001363586

NM_001162375
NM_174868

RefSeq (protein)

NP_001257313
NP_940951
NP_001350512
NP_001350513
NP_001350515

NP_001155847
NP_777357

Location (UCSC)Chr 1: 77.78 – 77.88 MbChr 3: 151.98 – 152.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitoguardin 1 is a protein that in humans is encoded by the MIGA1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180488 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054942 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mitoguardin 1". Retrieved 2016-08-16.

Further reading

  • Zhang Y, Liu X, Bai J, Tian X, Zhao X, Liu W, Duan X, Shang W, Fan HY, Tong C (2016). "Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis". Mol. Cell. 61 (1): 111–24. doi:10.1016/j.molcel.2015.11.017. PMID 26711011.


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