Myosin-IIIa

Protein-coding gene in the species Homo sapiens

MYO3A

Identifiers

Aliases

MYO3A, myosin IIIA, DFNB30

External IDs

OMIM: 606808; MGI: 2183924; HomoloGene: 49486; GeneCards: MYO3A; OMA:MYO3A - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p12.1	Start	25,934,229 bp^[1]
Band	10p12.1	End	26,212,532 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	22,232,314 bp^[2]
Band	2\|2 A3	End	22,508,264 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

testicle

gonad

sperm

ventricular zone

right testis

left testis

ganglionic eminence

epithelium of colon

popliteal artery

Top expressed in

morula

embryo

embryo

zygote

secondary oocyte

tail of embryo

blastocyst

spermatid

duodenum

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity protein kinase activity nucleotide binding ADP binding calmodulin binding kinase activity microfilament motor activity protein serine/threonine kinase activity plus-end directed microfilament motor activity actin binding cytoskeletal motor activity ATP binding protein binding
Cellular component	filamentous actin filopodium cytoskeleton myosin complex cytoplasm stereocilium tip stereocilium filopodium tip cell projection
Biological process	phosphorylation response to stimulus protein phosphorylation protein autophosphorylation visual perception hearing cochlea morphogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


53904


667663

Ensembl


ENSG00000095777


ENSMUSG00000025716

UniProt


Q8NEV4


Q8K3H5

RefSeq (mRNA)


NM_017433 NM_001368265


NM_148413

RefSeq (protein)


NP_059129 NP_001355194


n/a

Location (UCSC)

Chr 10: 25.93 – 26.21 Mb

Chr 2: 22.23 – 22.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.^[5]^[6]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095777 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025716 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dose AC, Burnside B (Sep 2000). "Cloning and chromosomal localization of a human class III myosin". Genomics. 67 (3): 333–42. doi:10.1006/geno.2000.6256. PMID 10936054.
^ ^a ^b "Entrez Gene: MYO3A myosin IIIA".

Walsh T, Walsh V, Vreugde S, et al. (2002). "From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7518–23. Bibcode:2002PNAS...99.7518W. doi:10.1073/pnas.102091699. PMC 124268. PMID 12032315.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Komaba S, Inoue A, Maruta S, et al. (2003). "Determination of human myosin III as a motor protein having a protein kinase activity". J. Biol. Chem. 278 (24): 21352–60. doi:10.1074/jbc.M300757200. PMID 12672820.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Kambara T, Komaba S, Ikebe M (2007). "Human myosin III is a motor having an extremely high affinity for actin". J. Biol. Chem. 281 (49): 37291–301. doi:10.1074/jbc.M603823200. PMID 17012748.
Schneider ME, Dosé AC, Salles FT, et al. (2006). "A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression". J. Neurosci. 26 (40): 10243–52. doi:10.1523/JNEUROSCI.2812-06.2006. PMC 6674622. PMID 17021180.
Dosé AC, Ananthanarayanan S, Moore JE, et al. (2007). "Kinetic mechanism of human myosin IIIA". J. Biol. Chem. 282 (1): 216–31. doi:10.1074/jbc.M605964200. PMID 17074769.

Cirilo JA Jr, Gunther LK, Yengo CM (2021). "Functional Role of Class III Myosins in Hair Cells". Front. Cell Dev. Biol. 9: 643856. doi:10.3389/fcell.2021.643856. PMC 7947357. PMID 33718386.

Proteins of the cytoskeleton

Human

Microfilaments
and ABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
and MAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3