NABP1

Protein-coding gene in the species Homo sapiens
NABP1
Identifiers
AliasesNABP1, OBFC2A, SOSS-B2, SSB2, nucleic acid binding protein 1
External IDsOMIM: 612103; MGI: 1923258; HomoloGene: 57094; GeneCards: NABP1; OMA:NABP1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NABP1
Genomic location for NABP1
Band2q32.3Start191,678,068 bp[1]
End191,741,097 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for NABP1
Genomic location for NABP1
Band1|1 C1.1Start51,505,021 bp[2]
End51,517,584 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • amniotic fluid

  • parietal pleura

  • spleen

  • stromal cell of endometrium

  • epithelium of nasopharynx

  • decidua

  • sperm

  • blood

  • visceral pleura
Top expressed in
  • transitional epithelium of urinary bladder

  • thymus

  • seminiferous tubule

  • spermatid

  • right kidney

  • granulocyte

  • brown adipose tissue

  • yolk sac

  • intercostal muscle

  • white adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • single-stranded DNA binding
  • DNA binding
  • protein binding
  • RNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • SOSS complex
Biological process
  • response to ionizing radiation
  • double-strand break repair via homologous recombination
  • DNA repair
  • cellular response to DNA damage stimulus
  • snRNA transcription by RNA polymerase II
  • mitotic cell cycle checkpoint signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64859

109019

Ensembl

ENSG00000173559

ENSMUSG00000026107

UniProt

Q96AH0

Q8BGW5

RefSeq (mRNA)

NM_001031716
NM_001254736
NM_022837

NM_028696
NM_001310548
NM_001310549

RefSeq (protein)

NP_001026886
NP_001241665

NP_001297477
NP_001297478
NP_082972

Location (UCSC)Chr 2: 191.68 – 191.74 MbChr 1: 51.51 – 51.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleic acid binding protein 1 is a protein that in humans is encoded by the NABP1 gene.[5]

Function

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173559 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026107 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nucleic acid binding protein 1".
  6. ^ Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (May 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

Further reading

  • Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W (August 2009). "HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response". The Journal of Biological Chemistry. 284 (35): 23525–31. doi:10.1074/jbc.C109.039586. PMC 2749126. PMID 19605351.
  • Huang J, Gong Z, Ghosal G, Chen J (August 2009). "SOSS complexes participate in the maintenance of genomic stability". Molecular Cell. 35 (3): 384–93. doi:10.1016/j.molcel.2009.06.011. PMC 2756616. PMID 19683501.
  • Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J (February 2010). "Streamlined analysis schema for high-throughput identification of endogenous protein complexes". Proceedings of the National Academy of Sciences of the United States of America. 107 (6): 2431–6. Bibcode:2010PNAS..107.2431M. doi:10.1073/pnas.0912599106. PMC 2823922. PMID 20133760.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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