NDFIP1

Protein-coding gene in the species Homo sapiens
NDFIP1
Identifiers
AliasesNDFIP1, N4WBP5, Nedd4 family interacting protein 1
External IDsOMIM: 612050; MGI: 1929601; HomoloGene: 12730; GeneCards: NDFIP1; OMA:NDFIP1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NDFIP1
Genomic location for NDFIP1
Band5q31.3Start142,108,779 bp[1]
End142,154,440 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NDFIP1
Genomic location for NDFIP1
Band18|18 B3Start38,543,449 bp[2]
End38,598,356 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • endothelial cell

  • pons

  • middle temporal gyrus

  • superior frontal gyrus

  • entorhinal cortex

  • postcentral gyrus

  • lateral nuclear group of thalamus

  • spinal ganglia

  • primary visual cortex
Top expressed in
  • cingulate gyrus

  • Epithelium of choroid plexus

  • medial dorsal nucleus

  • mammillary body

  • ventral tegmental area

  • dorsomedial hypothalamic nucleus

  • ventromedial nucleus

  • median eminence

  • seminal vesicula

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signal transducer activity
  • protein binding
  • WW domain binding
Cellular component
  • integral component of membrane
  • endosome
  • membrane
  • Golgi membrane
  • extracellular region
  • cell cortex
  • perinuclear region of cytoplasm
  • endosome membrane
  • cell junction
  • dendrite
  • cell projection
  • neuron projection
  • synapse
  • Golgi apparatus
Biological process
  • regulation of myeloid leukocyte differentiation
  • regulation of isotype switching to IgG isotypes
  • positive regulation of protein catabolic process
  • negative regulation of interleukin-4 production
  • metal ion transport
  • negative regulation of isotype switching to IgE isotypes
  • negative regulation of gene expression
  • negative regulation of T cell proliferation
  • regulation of lymphocyte differentiation
  • negative regulation of protein transport
  • negative regulation of type 2 immune response
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of protein ubiquitination
  • negative regulation of inflammatory response
  • negative regulation of transporter activity
  • vacuolar transport
  • cellular iron ion homeostasis
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80762

65113

Ensembl

ENSG00000131507

ENSMUSG00000024425

UniProt

Q9BT67

Q8R0W6

RefSeq (mRNA)

NM_030571

NM_022996
NM_001355749

RefSeq (protein)

NP_085048

NP_075372
NP_001342678

Location (UCSC)Chr 5: 142.11 – 142.15 MbChr 18: 38.54 – 38.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. [5]

Function

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131507 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024425 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nedd4 family interacting protein 1". Retrieved 2017-10-18.

Further reading

  • Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS (2008). "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins". J. Biol. Chem. 283 (47): 32621–7. doi:10.1074/jbc.M804120200. PMID 18819914.
  • Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
  • Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. Bibcode:2009PNAS..10615489H. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
  • Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. Bibcode:2010PNAS..10711429M. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
  • Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
  • Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
  • Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLOS ONE. 9 (1): e87119. Bibcode:2014PLoSO...987119H. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
  • Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
  • Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.