Protein-coding gene in the species Homo sapiens
NDFIP1 |
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Identifiers |
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Aliases | NDFIP1, N4WBP5, Nedd4 family interacting protein 1 |
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External IDs | OMIM: 612050; MGI: 1929601; HomoloGene: 12730; GeneCards: NDFIP1; OMA:NDFIP1 - orthologs |
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Gene location (Human) |
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![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
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| Band | 5q31.3 | Start | 142,108,779 bp[1] |
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End | 142,154,440 bp[1] |
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Gene location (Mouse) |
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![Chromosome 18 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png) | Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18|18 B3 | Start | 38,543,449 bp[2] |
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End | 38,598,356 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- endothelial cell
- pons
- middle temporal gyrus
- superior frontal gyrus
- entorhinal cortex
- postcentral gyrus
- lateral nuclear group of thalamus
- spinal ganglia
- primary visual cortex
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| Top expressed in | - cingulate gyrus
- Epithelium of choroid plexus
- medial dorsal nucleus
- mammillary body
- ventral tegmental area
- dorsomedial hypothalamic nucleus
- ventromedial nucleus
- median eminence
- seminal vesicula
- paraventricular nucleus of hypothalamus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - signal transducer activity
- protein binding
- WW domain binding
| Cellular component | - integral component of membrane
- endosome
- membrane
- Golgi membrane
- extracellular region
- cell cortex
- perinuclear region of cytoplasm
- endosome membrane
- cell junction
- dendrite
- cell projection
- neuron projection
- synapse
- Golgi apparatus
| Biological process | - regulation of myeloid leukocyte differentiation
- regulation of isotype switching to IgG isotypes
- positive regulation of protein catabolic process
- negative regulation of interleukin-4 production
- metal ion transport
- negative regulation of isotype switching to IgE isotypes
- negative regulation of gene expression
- negative regulation of T cell proliferation
- regulation of lymphocyte differentiation
- negative regulation of protein transport
- negative regulation of type 2 immune response
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of protein ubiquitination
- negative regulation of inflammatory response
- negative regulation of transporter activity
- vacuolar transport
- cellular iron ion homeostasis
- signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 5: 142.11 – 142.15 Mb | Chr 18: 38.54 – 38.6 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. [5]
Function
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131507 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024425 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Nedd4 family interacting protein 1". Retrieved 2017-10-18.
Further reading
- Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
- Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. Bibcode:2009PNAS..10615489H. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
- Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. Bibcode:2010PNAS..10711429M. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
- Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
- Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
- Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLOS ONE. 9 (1): e87119. Bibcode:2014PLoSO...987119H. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
- Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
- Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.