NEIL3

Protein-coding gene in the species Homo sapiens
NEIL3
Identifiers
AliasesNEIL3, FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
External IDsOMIM: 608934; MGI: 2384588; HomoloGene: 10094; GeneCards: NEIL3; OMA:NEIL3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NEIL3
Genomic location for NEIL3
Band4q34.3Start177,309,874 bp[1]
End177,362,936 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NEIL3
Genomic location for NEIL3
Band8|8 B1.3Start54,039,902 bp[2]
End54,092,100 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • ventricular zone

  • testicle

  • secondary oocyte

  • ganglionic eminence

  • stromal cell of endometrium

  • bone marrow

  • pancreatic ductal cell

  • bone marrow cells

  • rectum
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • thymus

  • genital tubercle

  • spermatid

  • tail of embryo

  • tibiofemoral joint

  • fetal liver hematopoietic progenitor cell

  • granulocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • zinc ion binding
  • hydrolase activity, hydrolyzing N-glycosyl compounds
  • metal ion binding
  • hydrolase activity, acting on glycosyl bonds
  • damaged DNA binding
  • catalytic activity
  • lyase activity
  • nucleic acid binding
  • hydrolase activity
  • DNA N-glycosylase activity
  • bubble DNA binding
  • DNA-(apurinic or apyrimidinic site) endonuclease activity
  • single-stranded DNA binding
  • double-stranded DNA binding
  • class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Cellular component
  • nucleoplasm
  • nucleus
Biological process
  • nucleotide-excision repair
  • cellular response to DNA damage stimulus
  • metabolism
  • DNA repair
  • base-excision repair
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55247

234258

Ensembl

ENSG00000109674

ENSMUSG00000039396

UniProt

Q8TAT5

Q8K203

RefSeq (mRNA)

NM_018248

NM_146208

RefSeq (protein)

NP_060718

NP_666320

Location (UCSC)Chr 4: 177.31 – 177.36 MbChr 8: 54.04 – 54.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.[5]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109674 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039396 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)".
  6. ^ Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.


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