NEURL

Protein-coding gene in the species Homo sapiens
NEURL1
Identifiers
AliasesNEURL1, NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1, neuralized E3 ubiquitin protein ligase 1
External IDsOMIM: 603804; MGI: 1334263; HomoloGene: 32503; GeneCards: NEURL1; OMA:NEURL1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for NEURL1
Genomic location for NEURL1
Band10q24.33Start103,493,705 bp[1]
End103,592,546 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for NEURL1
Genomic location for NEURL1
Band19 C3|19 39.39 cMStart47,167,259 bp[2]
End47,247,880 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • right hemisphere of cerebellum

  • gastrocnemius muscle

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • prefrontal cortex

  • nucleus accumbens

  • Brodmann area 9

  • amygdala
Top expressed in
  • muscle of thigh

  • superior frontal gyrus

  • triceps brachii muscle

  • primary visual cortex

  • temporal muscle

  • dentate gyrus of hippocampal formation granule cell

  • sternocleidomastoid muscle

  • skeletal muscle tissue

  • digastric muscle

  • vastus lateralis muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • translation factor activity, non-nucleic acid binding
  • ubiquitin protein ligase activity
  • metal ion binding
  • ubiquitin-protein transferase activity
  • transferase activity
Cellular component
  • cytoplasm
  • perikaryon
  • postsynaptic membrane
  • cell projection
  • membrane
  • postsynaptic density
  • plasma membrane
  • dendritic spine
  • synapse
  • cell junction
  • dendrite
  • perinuclear region of cytoplasm
  • apical dendrite
Biological process
  • Notch signaling pathway
  • flagellated sperm motility
  • positive regulation of epidermal growth factor-activated receptor activity
  • positive regulation of dendritic spine development
  • protein monoubiquitination
  • nervous system development
  • sperm axoneme assembly
  • positive regulation of synapse maturation
  • brain development
  • positive regulation of long-term neuronal synaptic plasticity
  • protein ubiquitination
  • positive regulation of apoptotic process
  • cellular response to amino acid stimulus
  • lactation
  • skeletal muscle tissue development
  • positive regulation of filopodium assembly
  • regulation of translation
  • negative regulation of cell population proliferation
  • negative regulation of Notch signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9148

18011

Ensembl

ENSG00000107954

ENSMUSG00000006435

UniProt

O76050

Q923S6

RefSeq (mRNA)

NM_004210

NM_001163480
NM_021360

RefSeq (protein)

NP_004201

NP_001156952
NP_067335

Location (UCSC)Chr 10: 103.49 – 103.59 MbChr 19: 47.17 – 47.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene.[5][6]


See also

  • NEURL2 (gene)

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107954 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006435 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H (Apr 1998). "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region". Oncogene. 16 (8): 1009–19. doi:10.1038/sj.onc.1201618. PMID 9519875.
  6. ^ "Entrez Gene: NEURL neuralized homolog (Drosophila)".

Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Timmusk T, Palm K, Belluardo N, et al. (2002). "Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities". Mol. Cell. Neurosci. 20 (4): 649–68. doi:10.1006/mcne.2002.1148. PMID 12213446. S2CID 25771738.
  • Pavlopoulos E, Kokkinaki M, Koutelou E, et al. (2002). "Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neuralized gene". Biochim. Biophys. Acta. 1574 (3): 375–82. doi:10.1016/s0167-4781(01)00330-x. PMID 11997106.
  • Vollrath B, Pudney J, Asa S, et al. (2001). "Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland". Mol. Cell. Biol. 21 (21): 7481–94. doi:10.1128/MCB.21.21.7481-7494.2001. PMC 99920. PMID 11585928.


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