NFRKB

Protein-coding gene in the species Homo sapiens
NFRKB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3U21, 4UF6, 4WLP

Identifiers
AliasesNFRKB, INO80G, nuclear factor related to kappaB binding protein
External IDsOMIM: 164013; MGI: 2442410; HomoloGene: 4492; GeneCards: NFRKB; OMA:NFRKB - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NFRKB
Genomic location for NFRKB
Band11q24.3Start129,863,636 bp[1]
End129,895,590 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NFRKB
Genomic location for NFRKB
Band9|9 A4Start31,297,488 bp[2]
End31,332,629 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • secondary oocyte

  • testicle

  • endothelial cell

  • left lobe of thyroid gland

  • right uterine tube

  • right lobe of thyroid gland

  • gonad

  • skin of leg

  • left ovary
Top expressed in
  • secondary oocyte

  • superior cervical ganglion

  • primary oocyte

  • hand

  • otolith organ

  • zygote

  • utricle

  • medullary collecting duct

  • spermatocyte

  • thymus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protease binding
  • DNA binding
  • protein binding
Cellular component
  • nucleus
  • Ino80 complex
  • nucleoplasm
Biological process
  • DNA recombination
  • inflammatory response
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • DNA repair
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • protein deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4798

235134

Ensembl

ENSG00000170322

ENSMUSG00000042185

UniProt

Q6P4R8

Q6PIJ4

RefSeq (mRNA)

NM_001143835
NM_006165

NM_172766
NM_001359654

RefSeq (protein)

NP_001137307
NP_006156
NP_001137307.1

NP_766354
NP_001346583
NP_001392026
NP_001392027
NP_001392028

NP_001392030
NP_001392031

Location (UCSC)Chr 11: 129.86 – 129.9 MbChr 9: 31.3 – 31.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor related to kappa-B-binding protein is a protein that in humans is encoded by the NFRKB gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170322 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042185 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adams BS, Leung K, Meltzer PS, Lewis KA, Wagner-McPherson C, Evans GA, Nabel GJ (Dec 1992). "Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25" (PDF). Genomics. 14 (2): 270–4. doi:10.1016/S0888-7543(05)80216-2. hdl:2027.42/29810. PMID 1427843.
  6. ^ "Entrez Gene: NFRKB nuclear factor related to kappaB binding protein".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Urban MB, Schreck R, Baeuerle PA (1991). "NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit". EMBO J. 10 (7): 1817–25. doi:10.1002/j.1460-2075.1991.tb07707.x. PMC 452856. PMID 2050119.
  • Adams BS, Leung KY, Hanley EW, Nabel GJ (1992). "Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site". New Biol. 3 (11): 1063–73. PMID 1777480.


  • v
  • t
  • e