NOL6

Protein-coding gene in the species Homo sapiens

NOL6
Identifiers
AliasesNOL6, NRAP, UTP22, bA311H10.1, nucleolar protein 6
External IDsOMIM: 611532; MGI: 2140151; HomoloGene: 41505; GeneCards: NOL6; OMA:NOL6 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NOL6
Genomic location for NOL6
Band9p13.3Start33,461,353 bp[1]
End33,473,930 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for NOL6
Genomic location for NOL6
Band4|4 A5Start41,114,427 bp[2]
End41,124,455 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • olfactory zone of nasal mucosa

  • nasal epithelium

  • gastrocnemius muscle

  • skin of leg

  • right testis

  • left testis

  • tendon of biceps brachii

  • skin of abdomen

  • anterior pituitary
Top expressed in
  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • tibiofemoral joint

  • gastrula

  • epiblast

  • right ventricle

  • yolk sac

  • cerebellar cortex

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • condensed nuclear chromosome
  • small-subunit processome
  • nucleolus
  • mitochondrion
  • nucleus
  • CURI complex
  • chromosome
  • UTP-C complex
  • nucleoplasm
Biological process
  • tRNA export from nucleus
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

65083

230082

Ensembl

ENSG00000165271

ENSMUSG00000028430

UniProt

Q9H6R4

Q8R5K4

RefSeq (mRNA)

NM_139235
NM_022917
NM_130793

NM_139236
NM_139237

RefSeq (protein)

NP_075068
NP_631981

NP_631982

Location (UCSC)Chr 9: 33.46 – 33.47 MbChr 4: 41.11 – 41.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.[5][6][7]

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165271 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028430 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Utama B, Kennedy D, Ru K, Mattick JS (Mar 2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells. 7 (2): 115–32. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476. S2CID 21385000.
  6. ^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
  7. ^ a b "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)".

Further reading

  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.


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