NOL8

Protein-coding gene in the species Homo sapiens
NOL8
Identifiers
AliasesNOL8, C9orf34, NOP132, bA62C3.3, bA62C3.4, nucleolar protein 8
External IDsOMIM: 611534; MGI: 1918180; HomoloGene: 41210; GeneCards: NOL8; OMA:NOL8 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NOL8
Genomic location for NOL8
Band9q22.31Start92,297,358 bp[1]
End92,325,636 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for NOL8
Genomic location for NOL8
Band13 A5|13 25.36 cMStart49,806,554 bp[2]
End49,832,492 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • testicle

  • body of pancreas

  • body of uterus

  • skin of abdomen

  • canal of the cervix

  • left ovary

  • tibial nerve

  • right ovary

  • spleen
Top expressed in
  • zygote

  • spermatocyte

  • tail of embryo

  • genital tubercle

  • secondary oocyte

  • spermatid

  • seminiferous tubule

  • primary oocyte

  • Rostral migratory stream

  • hand
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • nucleolus
  • nucleus
  • ribonucleoprotein complex
Biological process
  • rRNA processing
  • protein localization to nucleolus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55035

70930

Ensembl

ENSG00000198000

ENSMUSG00000021392

UniProt

Q76FK4

Q3UHX0

RefSeq (mRNA)

NM_001256394
NM_017948
NM_001330722

NM_001081350
NM_001271397

RefSeq (protein)

NP_001243323
NP_001317651
NP_060418
NP_001243323.1

NP_001258326

Location (UCSC)Chr 9: 92.3 – 92.33 MbChr 13: 49.81 – 49.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar protein 8 is a protein that in humans is encoded by the NOL8 gene.[5][6]

Interactions

NOL8 has been shown to interact with RRAGA[7] and NIP7.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198000 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021392 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: NOL8 nucleolar protein 8".
  7. ^ a b Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J. Biol. Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
  • Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J. Biol. Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
  • Jinawath N, Furukawa Y, Nakamura Y (2004). "Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer". Cancer Sci. 95 (5): 430–5. doi:10.1111/j.1349-7006.2004.tb03227.x. PMC 11159714. PMID 15132771. S2CID 40861858.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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