NOSIP

Protein-coding gene in the species Homo sapiens
NOSIP
Identifiers
AliasesNOSIP, CGI-25, nitric oxide synthase interacting protein
External IDsOMIM: 616759; MGI: 1913644; HomoloGene: 9315; GeneCards: NOSIP; OMA:NOSIP - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NOSIP
Genomic location for NOSIP
Band19q13.33Start49,555,468 bp[1]
End49,590,262 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NOSIP
Genomic location for NOSIP
Band7|7 B3Start44,711,853 bp[2]
End44,727,634 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • granulocyte

  • right testis

  • body of pancreas

  • triceps brachii muscle

  • muscle of thigh

  • blood

  • mucosa of transverse colon

  • tendon of biceps brachii

  • glutes
Top expressed in
  • spermatid

  • spermatocyte

  • interventricular septum

  • lip

  • blastocyst

  • genital tubercle

  • granulocyte

  • otic vesicle

  • epiblast

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • transferase activity
  • RNA binding
  • ubiquitin protein ligase activity
Cellular component
  • cytoplasm
  • cytosol
  • Golgi membrane
  • nucleus
Biological process
  • negative regulation of catalytic activity
  • negative regulation of nitric-oxide synthase activity
  • multicellular organism development
  • protein ubiquitination
  • regulation of nitric-oxide synthase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51070

66394

Ensembl

ENSG00000142546

ENSMUSG00000003421

UniProt

Q9Y314

Q9D6T0

RefSeq (mRNA)

NM_001270960
NM_015953
NM_001363649

NM_001163684
NM_025533

RefSeq (protein)

NP_001257889
NP_057037
NP_001350578

NP_001157156
NP_079809

Location (UCSC)Chr 19: 49.56 – 49.59 MbChr 7: 44.71 – 44.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nitric oxide synthase-interacting protein is an enzyme that in humans is encoded by the NOSIP gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142546 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003421 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dedio J, Konig P, Wohlfart P, Schroeder C, Kummer W, Muller-Esterl W (Jan 2001). "NOSIP, a novel modulator of endothelial nitric oxide synthase activity". FASEB J. 15 (1): 79–89. doi:10.1096/fj.00-0078com. PMID 11149895. S2CID 34485514.
  6. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ^ "Entrez Gene: NOSIP nitric oxide synthase interacting protein".

Further reading

  • Schleicher M, Brundin F, Gross S, et al. (2005). "Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton". Mol. Cell. Biol. 25 (18): 8251–8. doi:10.1128/MCB.25.18.8251-8258.2005. PMC 1234313. PMID 16135813.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Dreyer J, Schleicher M, Tappe A, et al. (2005). "Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity". J. Neurosci. 24 (46): 10454–65. doi:10.1523/JNEUROSCI.2265-04.2004. PMC 6730309. PMID 15548660.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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