NREP

Protein-coding gene in the species Homo sapiens
NREP
Identifiers
AliasesNREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17, neuronal regeneration related protein
External IDsOMIM: 607332; MGI: 99444; HomoloGene: 70874; GeneCards: NREP; OMA:NREP - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NREP
Genomic location for NREP
Band5q22.1Start111,662,621 bp[1]
End111,997,464 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NREP
Genomic location for NREP
Band18|18 B1Start33,570,072 bp[2]
End33,597,082 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • paraflocculus of cerebellum

  • ganglionic eminence

  • tibia

  • ventricular zone

  • right hemisphere of cerebellum

  • pons

  • Brodmann area 46

  • cartilage tissue

  • frontal pole

  • tendon of biceps brachii
Top expressed in
  • external carotid artery

  • vestibular sensory epithelium

  • cerebellar vermis

  • Rostral migratory stream

  • Gonadal ridge

  • lobe of cerebellum

  • fossa

  • barrel cortex

  • condyle

  • internal carotid artery
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • nucleus
Biological process
  • regulation of neuron differentiation
  • axon regeneration
  • regulation of transforming growth factor beta receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9315

27528

Ensembl

ENSG00000134986

ENSMUSG00000042834

UniProt

Q16612

Q07475

RefSeq (mRNA)
NM_001142474
NM_001142475
NM_001142476
NM_001142477
NM_001142478

NM_001142479
NM_001142480
NM_001142481
NM_001142482
NM_001142483
NM_004772

NM_001109988
NM_001109989
NM_001267717
NM_053078

RefSeq (protein)
NP_001135946
NP_001135947
NP_001135948
NP_001135949
NP_001135950

NP_001135951
NP_001135952
NP_001135953
NP_001135954
NP_001135955
NP_004763

NP_001103458
NP_001103459
NP_001254646
NP_444308

Location (UCSC)Chr 5: 111.66 – 112 MbChr 18: 33.57 – 33.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal protein 3.1 is a protein that in humans is encoded by the NREP gene.[5][6][7] It is highly expressed in the brain.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134986 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042834 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.
  6. ^ Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.
  7. ^ "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".
  8. ^ "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.

Further reading

  • Taylor GA, Hudson E, Resau JH, Vande Woude GF (Feb 2000). "Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10.1074/jbc.275.6.4215. PMID 10660586.
  • Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58. doi:10.1172/JCI15614. PMC 151607. PMID 12417574.
  • McDonough WS, Tran NL, Berens ME (Sep 2005). "Regulation of glioma cell migration by serine-phosphorylated P311". Neoplasia. 7 (9): 862–72. doi:10.1593/neo.05190. PMC 1501936. PMID 16229809.
  • Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH (Jul 2006). "Identification of P311 as a potential gene regulating alveolar generation". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 48–54. doi:10.1165/rcmb.2005-0475OC. PMC 2658697. PMID 16484684.


  • v
  • t
  • e