NSMCE4A

Protein-coding gene in the species Homo sapiens
NSMCE4A
Identifiers
AliasesNSMCE4A, C10orf86, NS4EA, NSE4A, NSE4 homolog A, SMC5-SMC6 complex component
External IDsOMIM: 612987; MGI: 1915122; HomoloGene: 9745; GeneCards: NSMCE4A; OMA:NSMCE4A - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for NSMCE4A
Genomic location for NSMCE4A
Band10q26.13Start121,957,091 bp[1]
End121,975,217 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NSMCE4A
Genomic location for NSMCE4A
Band7|7 F3Start130,134,256 bp[2]
End130,174,848 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • gastric mucosa

  • parotid gland

  • body of pancreas

  • muscle layer of sigmoid colon

  • minor salivary glands

  • rectum

  • transverse colon

  • body of uterus
Top expressed in
  • mandibular prominence

  • endocardial cushion

  • maxillary prominence

  • epiblast

  • abdominal wall

  • medial ganglionic eminence

  • ventricular zone

  • hand

  • migratory enteric neural crest cell

  • atrioventricular valve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • telomere
  • Smc5-Smc6 complex
  • nucleus
  • chromosome
  • nucleoplasm
  • nuclear body
Biological process
  • DNA recombination
  • DNA repair
  • positive regulation of response to DNA damage stimulus
  • cellular response to DNA damage stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54780

67872

Ensembl

ENSG00000107672

ENSMUSG00000040331

UniProt

Q9NXX6

n/a

RefSeq (mRNA)

NM_001167865
NM_017615

NM_001162855

RefSeq (protein)

NP_001161337
NP_060085

n/a

Location (UCSC)Chr 10: 121.96 – 121.98 MbChr 7: 130.13 – 130.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Non-SMC element 4 homolog A is a protein that in humans is encoded by the NSMCE4A gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107672 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040331 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hu B, Liao C, Millson SH, Mollapour M, Prodromou C, Pearl LH, Piper PW, Panaretou B (Mar 2005). "Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex". Mol Microbiol. 55 (6): 1735–50. doi:10.1111/j.1365-2958.2005.04531.x. PMID 15752197. S2CID 40645007.
  6. ^ "Entrez Gene: NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)".

Further reading

  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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