NUDC

Protein-coding gene in the species Homo sapiens

NUDC

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3QOR

Identifiers

Aliases

NUDC, HMNPD011, nudC nuclear distribution protein, nuclear distribution C, dynein complex regulator

External IDs

OMIM: 610325; MGI: 106014; HomoloGene: 4812; GeneCards: NUDC; OMA:NUDC - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.11	Start	26,900,238 bp^[1]
Band	1p36.11	End	26,946,871 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.3	Start	133,259,853 bp^[2]
Band	4\|4 D2.3	End	133,273,307 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

right uterine tube

right adrenal gland

right adrenal cortex

left adrenal gland

left adrenal cortex

right frontal lobe

anterior cingulate cortex

olfactory zone of nasal mucosa

internal globus pallidus

Top expressed in

yolk sac

embryo

embryo

dentate gyrus of hippocampal formation granule cell

ventricular zone

zygote

superior frontal gyrus

neural layer of retina

primary visual cortex

tail of embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding cadherin binding unfolded protein binding
Cellular component	cytoplasm microtubule cytoskeleton nucleus nucleoplasm cytosol
Biological process	multicellular organism development cell division cell cycle cell population proliferation sister chromatid cohesion protein folding developmental process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10726


18221

Ensembl


ENSG00000090273


ENSMUSG00000028851

UniProt


Q9Y266


O35685

RefSeq (mRNA)


NM_006600


NM_010948

RefSeq (protein)


NP_006591


NP_035078

Location (UCSC)

Chr 1: 26.9 – 26.95 Mb

Chr 4: 133.26 – 133.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene.^[5]

Interactions

NUDC has been shown to interact with PLK1^[6] and PAFAH1B1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090273 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028851 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NUDC nuclear distribution gene C homolog (A. nidulans)".
^ Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL (Jul 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Developmental Cell. 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. PMID 12852857.
^ Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee LY (May 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Current Biology. 8 (10): 603–6. Bibcode:1998CBio....8..603M. doi:10.1016/S0960-9822(98)70232-5. PMID 9601647.

Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee LY (May 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Current Biology. 8 (10): 603–6. Bibcode:1998CBio....8..603M. doi:10.1016/S0960-9822(98)70232-5. PMID 9601647.
Miller BA, Zhang MY, Gocke CD, De Souza C, Osmani AH, Lynch C, Davies J, Bell L, Osmani SA (Apr 1999). "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis". Experimental Hematology. 27 (4): 742–50. doi:10.1016/S0301-472X(98)00074-5. PMID 10210332.
Matsumoto N, Ledbetter DH (Jun 1999). "Molecular cloning and characterization of the human NUDC gene". Human Genetics. 104 (6): 498–504. doi:10.1007/s004390050994. PMID 10453739. S2CID 6596735.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Aumais JP, Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark GD, Yu-Lee LY (Dec 2001). "NudC associates with Lis1 and the dynein motor at the leading pole of neurons". The Journal of Neuroscience. 21 (24): RC187. doi:10.1523/JNEUROSCI.21-24-j0002.2001. PMC 6763039. PMID 11734602.
Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY (May 2003). "Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis". Journal of Cell Science. 116 (Pt 10): 1991–2003. doi:10.1242/jcs.00412. PMID 12679384. S2CID 186972.
Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL (Jul 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Developmental Cell. 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. PMID 12852857.
Lin SH, Nishino M, Luo W, Aumais JP, Galfione M, Kuang J, Yu-Lee LY (Apr 2004). "Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein". Oncogene. 23 (14): 2499–506. doi:10.1038/sj.onc.1207343. PMID 14676831.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Pan RM, Yang Y, Wei MX, Yu XB, Ge YC, Xu P (Nov 2005). "A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl)". Journal of Cellular Biochemistry. 96 (4): 741–50. doi:10.1002/jcb.20573. PMID 16088917. S2CID 426115.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR, Yu-Lee LY (Jul 2006). "NudC is required for Plk1 targeting to the kinetochore and chromosome congression". Current Biology. 16 (14): 1414–21. Bibcode:2006CBio...16.1414N. doi:10.1016/j.cub.2006.05.052. PMID 16860740. S2CID 14293580.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.