NUDCD3

Protein-coding gene in the species Homo sapiens
NUDCD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WGV

Identifiers
AliasesNUDCD3, NudCL, NudC domain containing 3
External IDsOMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for NUDCD3
Genomic location for NUDCD3
Band7p13Start44,379,119 bp[1]
End44,490,658 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NUDCD3
Genomic location for NUDCD3
Band11|11 A1Start6,055,691 bp[2]
End6,150,415 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • right frontal lobe

  • Brodmann area 9

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • gastrocnemius muscle

  • stromal cell of endometrium

  • nucleus accumbens

  • islet of Langerhans

  • muscle of thigh
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • muscle of thigh

  • primary visual cortex

  • superior frontal gyrus

  • dorsomedial hypothalamic nucleus

  • cerebellar cortex

  • piriform cortex

  • temporal muscle

  • subiculum

  • triceps brachii muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • unfolded protein binding
Cellular component
  • cytoplasm
  • cytoplasmic dynein complex
Biological process
  • protein folding
  • cilium assembly
  • protein localization to pericentriolar material
  • developmental process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23386

209586

Ensembl

ENSG00000015676

ENSMUSG00000053838

UniProt

Q8IVD9

Q8R1N4

RefSeq (mRNA)

NM_015332

NM_173748
NM_001363446

RefSeq (protein)

NP_056147

NP_776109
NP_001350375

Location (UCSC)Chr 7: 44.38 – 44.49 MbChr 11: 6.06 – 6.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.[5]

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015676 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053838 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NUDCD3 NudC domain containing 3".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. Bibcode:2006PNAS..103.9039Z. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.
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