NUPL2

Protein-coding gene in the species Homo sapiens
NUP42
Identifiers
AliasesNUP42, CG1, NLP-1, NLP_1, hCG1, nucleoporin like 2, NUPL2, nucleoporin 42
External IDsMGI: 2387631; HomoloGene: 40573; GeneCards: NUP42; OMA:NUP42 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for NUP42
Genomic location for NUP42
Band7p15.3Start23,181,841 bp[1]
End23,201,011 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for NUP42
Genomic location for NUP42
Band5|5 A3Start24,369,961 bp[2]
End24,389,011 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • monocyte

  • right hemisphere of cerebellum

  • rectum

  • right uterine tube

  • right testis

  • left testis

  • right adrenal cortex

  • gonad

  • spleen
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • interventricular septum

  • internal carotid artery

  • external carotid artery

  • embryo

  • muscle of thigh

  • embryo

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nuclear export signal receptor activity
  • metal ion binding
  • protein binding
  • RNA binding
Cellular component
  • nuclear membrane
  • nuclear envelope
  • membrane
  • nuclear pore
  • nucleoplasm
  • nucleus
  • cytosol
  • host cell
Biological process
  • mRNA transport
  • viral transcription
  • protein sumoylation
  • mitotic nuclear membrane disassembly
  • protein export from nucleus
  • regulation of cellular response to heat
  • protein transport
  • viral process
  • intracellular transport of virus
  • mRNA export from nucleus
  • tRNA export from nucleus
  • regulation of gene silencing by miRNA
  • regulation of glycolytic process
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11097

231042

Ensembl

ENSG00000136243

ENSMUSG00000048439

UniProt

O15504

Q8CIC2

RefSeq (mRNA)

NM_007342
NM_001370443
NM_001370444
NM_001370445
NM_001370446

NM_153092
NM_001346582

RefSeq (protein)

NP_031368
NP_001357372
NP_001357373
NP_001357374
NP_001357375

NP_001333511
NP_694732

Location (UCSC)Chr 7: 23.18 – 23.2 MbChr 5: 24.37 – 24.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136243 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048439 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem. 274 (24): 17309–17317. doi:10.1074/jbc.274.24.17309. PMID 10358091.
  6. ^ Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet. 5 (6): 397–405. PMID 9450185.
  7. ^ "Entrez Gene: NUPL2 nucleoporin like 2".

Further reading

  • Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. doi:10.1128/JVI.72.7.6004-6013.1998. PMC 110405. PMID 9621063.
  • Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–2609. doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171.
  • Strahm Y, Fahrenkrog B, Zenklusen D, et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p". EMBO J. 18 (20): 5761–5777. doi:10.1093/emboj/18.20.5761. PMC 1171643. PMID 10610322.
  • de Noronha CM, Sherman MP, Lin HW, et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr". Science. 294 (5544): 1105–1108. Bibcode:2001Sci...294.1105D. doi:10.1126/science.1063957. PMID 11691994. S2CID 29771914.
  • Le Rouzic E, Mousnier A, Rustum C, et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–45098. doi:10.1074/jbc.M207439200. PMID 12228227.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sasaki M, Takeda E, Takano K, et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products". Genomics. 85 (5): 641–653. doi:10.1016/j.ygeno.2005.01.003. PMID 15820316.
  • Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA". Mol. Biol. Cell. 16 (9): 4304–4315. doi:10.1091/mbc.E04-11-0998. PMC 1196339. PMID 16000379.
  • Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion. 4 (2–3): 223–233. doi:10.1016/j.mito.2004.06.012. PMID 16120388.


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