NXPH1

Protein-coding gene in the species Homo sapiens
NXPH1
Identifiers
AliasesNXPH1, NPH1, Nbla00697, neurexophilin 1
External IDsOMIM: 604639; MGI: 107492; HomoloGene: 8284; GeneCards: NXPH1; OMA:NXPH1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for NXPH1
Genomic location for NXPH1
Band7p21.3Start8,433,609 bp[1]
End8,752,961 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for NXPH1
Genomic location for NXPH1
Band6|6 A1Start8,948,431 bp[2]
End9,249,032 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • endothelial cell

  • secondary oocyte

  • prefrontal cortex

  • testicle

  • left adrenal gland

  • left adrenal cortex

  • hypothalamus

  • cingulate gyrus

  • anterior cingulate cortex
Top expressed in
  • lateral septal nucleus

  • medial dorsal nucleus

  • dorsomedial hypothalamic nucleus

  • ventral tegmental area

  • anterior amygdaloid area

  • dorsal tegmental nucleus

  • medial vestibular nucleus

  • habenula

  • lumbar subsegment of spinal cord

  • ventromedial nucleus
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

30010

18231

Ensembl

ENSG00000122584

ENSMUSG00000046178

UniProt

P58417

Q61200

RefSeq (mRNA)

NM_152745

NM_008751

RefSeq (protein)

NP_689958

NP_032777

Location (UCSC)Chr 7: 8.43 – 8.75 MbChr 6: 8.95 – 9.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.[5][6]

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122584 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046178 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.
  6. ^ a b "Entrez Gene: NXPH1 neurexophilin 1".

Further reading

  • Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
  • Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi:10.1523/JNEUROSCI.16-14-04360.1996. PMC 6578849. PMID 8699246.
  • Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi:10.1074/jbc.273.52.34716. PMID 9856994.
  • Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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