Neurotrimin

Protein-coding gene in the species Homo sapiens
NTM
Identifiers
AliasesNTM, HNT, IGLON2, NTRI, neurotrimin, CEPU-1
External IDsOMIM: 607938; MGI: 2446259; HomoloGene: 41139; GeneCards: NTM; OMA:NTM - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NTM
Genomic location for NTM
Band11q25Start131,370,478 bp[1]
End132,336,822 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NTM
Genomic location for NTM
Band9|9 A4Start28,906,046 bp[2]
End29,874,437 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • cerebellar vermis

  • primary visual cortex

  • middle temporal gyrus

  • postcentral gyrus

  • Brodmann area 23

  • superior frontal gyrus

  • corpus callosum

  • right frontal lobe

  • Brodmann area 9
Top expressed in
  • primary motor cortex

  • visual cortex

  • cerebellar cortex

  • primary visual cortex

  • cerebellar vermis

  • lobe of cerebellum

  • superior frontal gyrus

  • prefrontal cortex

  • mammillary body

  • lateral geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • anchored component of membrane
  • membrane
  • extracellular region
  • plasma membrane
Biological process
  • neuron recognition
  • cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50863

235106

Ensembl

ENSG00000182667

ENSMUSG00000059974

UniProt

Q9P121

Q99PJ0

RefSeq (mRNA)
NM_001048209
NM_001144058
NM_001144059
NM_016522
NM_001352001

NM_001352002
NM_001352003
NM_001352004
NM_001352005
NM_001352006
NM_001352007
NM_001352008
NM_001352009

NM_172290
NM_001357593
NM_001357597
NM_001357598
NM_001357601

NM_001357602
NM_001357603

RefSeq (protein)
NP_001041674
NP_001137530
NP_001137531
NP_057606
NP_001338930

NP_001338931
NP_001338932
NP_001338933
NP_001338934
NP_001338935
NP_001338936
NP_001338937
NP_001338938

NP_758494
NP_001344522
NP_001344526
NP_001344527
NP_001344530

NP_001344531
NP_001344532

Location (UCSC)Chr 11: 131.37 – 132.34 MbChr 9: 28.91 – 29.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurotrimin is a protein that in humans is encoded by the NTM gene.[5][6]

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182667 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059974 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi:10.1523/JNEUROSCI.15-03-02141.1995. PMC 6578143. PMID 7891157.
  6. ^ a b "Entrez Gene: HNT neurotrimin".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783. S2CID 24411276.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene". Science in China Series C: Life Sciences. 47 (2): 158–64. doi:10.1360/03yc0072. PMID 15379248. S2CID 12684887.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


  • v
  • t
  • e