OR13C8

Protein-coding gene in the species Homo sapiens
OR13C8
Identifiers
AliasesOR13C8, OR37H, OR9-10, olfactory receptor family 13 subfamily C member 8
External IDsMGI: 3030106; HomoloGene: 17409; GeneCards: OR13C8; OMA:OR13C8 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OR13C8
Genomic location for OR13C8
Band9q31.1Start104,569,168 bp[1]
End104,570,130 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for OR13C8
Genomic location for OR13C8
Band4|4 B2Start52,910,207 bp[2]
End52,919,178 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • respiratory epithelium

  • peripheral nervous system

  • nasal epithelium

  • olfactory epithelium

  • lens
BioGPS
More reference expression data
Gene ontology
Molecular function
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

138802

258836

Ensembl

ENSG00000186943

ENSMUSG00000051593

UniProt

Q8NGS7

Q8VGA0

RefSeq (mRNA)

NM_001004483

NM_146839

RefSeq (protein)

NP_001004483

NP_667050

Location (UCSC)Chr 9: 104.57 – 104.57 MbChr 4: 52.91 – 52.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 13C8 is a protein that in humans is encoded by the OR13C8 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186943 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051593 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR13C8 olfactory receptor, family 13, subfamily C, member 8".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Hoppe R, Breer H, Strotmann J (2004). "Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human". Genomics. 82 (3): 355–64. doi:10.1016/S0888-7543(03)00116-2. PMID 12906860.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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