OSBP2

Protein-coding gene in the species Homo sapiens
OSBP2
Identifiers
AliasesOSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2
External IDsOMIM: 606729; MGI: 1921559; HomoloGene: 75303; GeneCards: OSBP2; OMA:OSBP2 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for OSBP2
Genomic location for OSBP2
Band22q12.2Start30,693,782 bp[1]
End30,907,824 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for OSBP2
Genomic location for OSBP2
Band11|11 A1Start3,653,731 bp[2]
End3,813,903 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • left testis

  • right testis

  • monocyte

  • right hemisphere of cerebellum

  • blood

  • prefrontal cortex

  • right frontal lobe

  • trabecular bone

  • male germ cell
Top expressed in
  • spermatid

  • neural layer of retina

  • interventricular septum

  • seminiferous tubule

  • spermatocyte

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • retinal pigment epithelium

  • lens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cholesterol binding
  • protein binding
  • lipid binding
  • sterol transporter activity
  • sterol binding
Cellular component
  • membrane
  • apical dendrite
  • cytosol
  • plasma membrane
  • intracellular membrane-bounded organelle
  • perinuclear endoplasmic reticulum
Biological process
  • lipid transport
  • spermatid development
  • sterol transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23762

74309

Ensembl

ENSG00000184792

ENSMUSG00000020435

UniProt

Q969R2

Q5QNQ6

RefSeq (mRNA)
NM_001003812
NM_001282738
NM_001282739
NM_001282740
NM_001282741

NM_001282742
NM_030758

NM_152818
NM_001302630
NM_001302631
NM_001363163
NM_001363164

RefSeq (protein)
NP_001269667
NP_001269668
NP_001269669
NP_001269670
NP_001269671

NP_110385

NP_001289559
NP_001289560
NP_690031
NP_001350092
NP_001350093

Location (UCSC)Chr 22: 30.69 – 30.91 MbChr 11: 3.65 – 3.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.[5][6][7][8]

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184792 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020435 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. ^ Moreira EF, Jaworski C, Li A, Rodriguez IR (May 2001). "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina". J Biol Chem. 276 (21): 18570–8. doi:10.1074/jbc.M011259200. PMID 11278871.
  7. ^ Wang C, JeBailey L, Ridgway ND (Jan 2002). "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments". Biochem J. 361 (Pt 3): 461–72. doi:10.1042/0264-6021:3610461. PMC 1222328. PMID 11802775.
  8. ^ a b "Entrez Gene: OSBP2 oxysterol binding protein 2".

Further reading

  • Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
  • Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Henriques Silva N, Vasconcellos Fournier M, Pimenta G, et al. (2004). "HLM/OSBP2 is expressed in chronic myeloid leukemia". Int. J. Mol. Med. 12 (4): 663–6. doi:10.3892/ijmm.12.4.663. PMID 12964051.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Wyles JP, Perry RJ, Ridgway ND (2007). "Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization". Exp. Cell Res. 313 (7): 1426–37. doi:10.1016/j.yexcr.2007.01.018. PMID 17350617.


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