OSBPL11

Protein-coding gene in the species Homo sapiens

OSBPL11

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2D9X

Identifiers

Aliases

OSBPL11, ORP-11, ORP11, OSBP12, TCCCIA00292, oxysterol binding protein like 11

External IDs

OMIM: 606739; MGI: 2146553; HomoloGene: 23385; GeneCards: OSBPL11; OMA:OSBPL11 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q21.2	Start	125,528,858 bp^[1]
Band	3q21.2	End	125,595,497 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B3	Start	33,005,441 bp^[2]
Band	16\|16 B3	End	33,063,682 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

biceps brachii

Skeletal muscle tissue of biceps brachii

vastus lateralis muscle

thoracic diaphragm

deltoid muscle

gastrocnemius muscle

monocyte

tibialis anterior muscle

Skeletal muscle tissue of rectus abdominis

secondary oocyte

Top expressed in

cumulus cell

gastrula

primary oocyte

secondary oocyte

stroma of bone marrow

ureter

primitive streak

Rostral migratory stream

zygote

lens

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	lipid binding sterol transporter activity sterol binding
Cellular component	endosome membrane late endosome membrane nucleoplasm Golgi apparatus cytosol intracellular membrane-bounded organelle
Biological process	lipid transport positive regulation of sequestering of triglyceride fat cell differentiation sterol transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


114885


106326

Ensembl


ENSG00000144909


ENSMUSG00000022807

UniProt


Q9BXB4


Q8CI95

RefSeq (mRNA)


NM_022776


NM_176840

RefSeq (protein)


NP_073613


NP_789810

Location (UCSC)

Chr 3: 125.53 – 125.6 Mb

Chr 16: 33.01 – 33.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.^[5]

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144909 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022807 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OSBPL11 oxysterol binding protein-like 11".

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.