OSBPL3

Protein-coding gene in the species Homo sapiens

OSBPL3
Identifiers
AliasesOSBPL3, ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDsOMIM: 606732; MGI: 1918970; HomoloGene: 49422; GeneCards: OSBPL3; OMA:OSBPL3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for OSBPL3
Genomic location for OSBPL3
Band7p15.3Start24,796,540 bp[1]
End24,981,634 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OSBPL3
Genomic location for OSBPL3
Band6|6 B2.3Start50,270,310 bp[2]
End50,433,181 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • amniotic fluid

  • oocyte

  • secondary oocyte

  • left lobe of thyroid gland

  • gonad

  • right lobe of thyroid gland

  • stromal cell of endometrium

  • mucosa of paranasal sinus

  • skin of abdomen
Top expressed in
  • transitional epithelium of urinary bladder

  • lumbar spinal ganglion

  • epithelium of stomach

  • proximal tubule

  • right kidney

  • human kidney

  • otolith organ

  • utricle

  • ascending aorta

  • adrenal gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cholesterol binding
  • protein binding
  • lipid binding
  • sterol transporter activity
  • sterol binding
Cellular component
  • perinuclear endoplasmic reticulum
  • cell projection
  • cytoplasm
  • endoplasmic reticulum membrane
  • filopodium tip
  • nuclear membrane
  • endoplasmic reticulum
  • plasma membrane
  • nucleus
  • membrane
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • lipid transport
  • bile acid biosynthetic process
  • sterol transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26031

71720

Ensembl

ENSG00000070882

ENSMUSG00000029822

UniProt

Q9H4L5

Q9DBS9

RefSeq (mRNA)
NM_015550
NM_145320
NM_145321
NM_145322
NM_145323

NM_145324

NM_001163645
NM_027881
NM_001347213

RefSeq (protein)

NP_056365
NP_663160
NP_663161
NP_663162

NP_001157117
NP_001334142
NP_082157

Location (UCSC)Chr 7: 24.8 – 24.98 MbChr 6: 50.27 – 50.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.[5][6]

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070882 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029822 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ a b "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

Further reading

  • Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Dec 1999). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". Journal of Lipid Research. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
  • Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (Aug 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
  • Gregorio-King CC, Collier GR, McMillan JS, Waugh CM, McLeod JL, Collier FM, Kirkland MA (Oct 2001). "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells". Blood. 98 (7): 2279–81. doi:10.1182/blood.V98.7.2279. PMID 11568019.
  • Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (Dec 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
  • Collier FM, Gregorio-King CC, Apostolopoulos J, Walder K, Kirkland MA (Jan 2003). "ORP3 splice variants and their expression in human tissues and hematopoietic cells". DNA and Cell Biology. 22 (1): 1–9. doi:10.1089/104454903321112442. hdl:10536/DRO/DU:30009437. PMID 12590732.
  • Lehto M, Tienari J, Lehtonen S, Lehtonen E, Olkkonen VM (Jan 2004). "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7". Cell and Tissue Research. 315 (1): 39–57. doi:10.1007/s00441-003-0817-y. PMID 14593528. S2CID 21298003.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM (Nov 2005). "Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants". Experimental Cell Research. 310 (2): 445–62. doi:10.1016/j.yexcr.2005.08.003. PMID 16143324.


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