OSBPL5

Protein-coding gene in the species Homo sapiens
OSBPL5
Identifiers
AliasesOSBPL5, OBPH1, ORP5, oxysterol binding protein like 5
External IDsOMIM: 606733; MGI: 1930265; HomoloGene: 98024; GeneCards: OSBPL5; OMA:OSBPL5 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OSBPL5
Genomic location for OSBPL5
Band11p15.4Start3,087,107 bp[1]
End3,166,739 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OSBPL5
Genomic location for OSBPL5
Band7 F5|7 88.29 cMStart143,242,499 bp[2]
End143,310,722 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • tendon of biceps brachii

  • canal of the cervix

  • granulocyte

  • sural nerve

  • ectocervix

  • popliteal artery

  • tibial arteries

  • thoracic aorta

  • Descending thoracic aorta
Top expressed in
  • Ileal epithelium

  • corneal stroma

  • sciatic nerve

  • lip

  • ankle joint

  • decidua

  • superior surface of tongue

  • plantaris muscle

  • cardiac muscle tissue of left ventricle

  • esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cholesterol binding
  • phosphatidylinositol-4-phosphate binding
  • oxysterol binding
  • phosphatidylserine binding
  • lipid binding
  • phospholipid transporter activity
  • sterol transporter activity
  • sterol binding
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • endoplasmic reticulum
  • cytosol
  • intracellular membrane-bounded organelle
  • endoplasmic reticulum-plasma membrane contact site
Biological process
  • phospholipid transport
  • cholesterol transport
  • lipid transport
  • cholesterol metabolic process
  • Golgi to plasma membrane transport
  • phosphatidylserine acyl-chain remodeling
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114879

79196

Ensembl

ENSG00000021762

ENSMUSG00000037606

UniProt

Q9H0X9

Q9ER64

RefSeq (mRNA)

NM_001144063
NM_020896
NM_145638

NM_001199227
NM_024289
NM_001384163

RefSeq (protein)

NP_001137535
NP_065947
NP_663613

NP_001186156
NP_077251
NP_001371092

Location (UCSC)Chr 11: 3.09 – 3.17 MbChr 7: 143.24 – 143.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.[5]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000021762 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037606 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OSBPL5 oxysterol binding protein-like 5".

Further reading

  • Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J. Lipid Res. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
  • Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Higashimoto K, Soejima H, Yatsuki H, et al. (2003). "Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse". Genomics. 80 (6): 575–84. doi:10.1006/geno.2002.7006. PMID 12504849.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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