OSBPL8

Protein-coding gene in the species Homo sapiens
OSBPL8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1V88

Identifiers
AliasesOSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDsOMIM: 606736; MGI: 2443807; HomoloGene: 68813; GeneCards: OSBPL8; OMA:OSBPL8 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for OSBPL8
Genomic location for OSBPL8
Band12q21.2Start76,351,797 bp[1]
End76,559,809 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for OSBPL8
Genomic location for OSBPL8
Band10|10 D1Start111,000,613 bp[2]
End111,133,110 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • lactiferous duct

  • trabecular bone

  • endothelial cell

  • nipple

  • skin of hip

  • Achilles tendon

  • visceral pleura

  • trigeminal ganglion

  • superficial temporal artery
Top expressed in
  • olfactory tubercle

  • zygote

  • nucleus accumbens

  • secondary oocyte

  • cumulus cell

  • olfactory epithelium

  • myocardium of ventricle

  • retinal pigment epithelium

  • interventricular septum

  • aortic valve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • phosphatidylserine binding
  • cholesterol binding
  • phosphatidylinositol-4-phosphate binding
  • lipid binding
  • phospholipid transporter activity
  • sterol transporter activity
  • sterol binding
Cellular component
  • integral component of membrane
  • nuclear membrane
  • endoplasmic reticulum membrane
  • membrane
  • cortical endoplasmic reticulum
  • endoplasmic reticulum
  • nucleus
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • activation of protein kinase B activity
  • positive regulation of protein kinase B signaling
  • lipid transport
  • protein localization to nuclear pore
  • phospholipid transport
  • negative regulation of cell migration
  • negative regulation of sequestering of triglyceride
  • positive regulation of insulin receptor signaling pathway
  • fat cell differentiation
  • phosphatidylserine acyl-chain remodeling
  • transport
  • sterol transport
  • positive regulation of glucose import
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114882

237542

Ensembl

ENSG00000091039

ENSMUSG00000020189

UniProt

Q9BZF1

B9EJ86

RefSeq (mRNA)

NM_001003712
NM_020841
NM_001319652
NM_001319653
NM_001319655

NM_001003717
NM_175489

RefSeq (protein)

NP_001003712
NP_001306581
NP_001306582
NP_001306584
NP_065892

NP_001003717
NP_780698

Location (UCSC)Chr 12: 76.35 – 76.56 MbChr 10: 111 – 111.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.[5][6][7]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091039 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020189 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pritchett JW (Mar 1992). "Longitudinal growth and growth-plate activity in the lower extremity". Clin Orthop Relat Res. 275 (275): 274–9. doi:10.1097/00003086-199202000-00041. PMID 1735225.
  6. ^ Yan D, Mayranpaa MI, Wong J, Perttila J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (Dec 2007). "OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages". J Biol Chem. 283 (1): 332–40. doi:10.1074/jbc.M705313200. PMID 17991739.
  7. ^ a b "Entrez Gene: OSBPL8 oxysterol binding protein-like 8".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
  • v
  • t
  • e
  • 1v88: Solution Structure of the Pleckstrin Homology Domain of Oxysterol-Binding Protein-Related Protein 8 (KIAA1451 Protein)
    1v88: Solution Structure of the Pleckstrin Homology Domain of Oxysterol-Binding Protein-Related Protein 8 (KIAA1451 Protein)


Stub icon

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e