OSBPL9

Protein-coding gene in the species Homo sapiens
OSBPL9
Identifiers
AliasesOSBPL9, ORP-9, ORP9, oxysterol binding protein like 9
External IDsOMIM: 606737; MGI: 1923784; HomoloGene: 69380; GeneCards: OSBPL9; OMA:OSBPL9 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OSBPL9
Genomic location for OSBPL9
Band1p32.3Start51,577,179 bp[1]
End51,798,427 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for OSBPL9
Genomic location for OSBPL9
Band4|4 C7Start109,061,145 bp[2]
End109,202,272 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • right lung

  • popliteal artery

  • tibial arteries

  • sural nerve

  • Epithelium of choroid plexus

  • renal medulla

  • retinal pigment epithelium

  • right coronary artery

  • gastric mucosa
Top expressed in
  • stroma of bone marrow

  • right kidney

  • granulocyte

  • proximal tubule

  • carotid body

  • iris

  • ankle

  • conjunctival fornix

  • vestibular membrane of cochlear duct

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • lipid binding
  • sterol transporter activity
  • sterol binding
Cellular component
  • endosome
  • Golgi apparatus
  • membrane
  • late endosome membrane
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • lipid transport
  • bile acid biosynthetic process
  • sterol transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114883

100273

Ensembl

ENSG00000117859

ENSMUSG00000028559

UniProt

Q96SU4

A2A8Z1

RefSeq (mRNA)
NM_024586
NM_148904
NM_148905
NM_148906
NM_148907

NM_148908
NM_148909
NM_001330580
NM_001350208
NM_001350209
NM_001350210

NM_001134791
NM_133885
NM_173350
NM_001346502
NM_001355190

NM_001355191
NM_001368727

RefSeq (protein)
NP_001317509
NP_078862
NP_683702
NP_683703
NP_683704

NP_683705
NP_683706
NP_683707
NP_001337137
NP_001337138
NP_001337139

NP_001128263
NP_001333431
NP_598646
NP_775485
NP_001342119

NP_001342120
NP_001355656

Location (UCSC)Chr 1: 51.58 – 51.8 MbChr 4: 109.06 – 109.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene.[5]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117859 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028559 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: oxysterol binding protein-like 9". Retrieved 2011-08-30.

Further reading

  • Ngo M, Ridgway ND (Mar 2009). "Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function". Molecular Biology of the Cell. 20 (5): 1388–99. doi:10.1091/mbc.E08-09-0905. PMC 2649274. PMID 19129476.
  • Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S (Jun 2009). "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach". Analytical Chemistry. 81 (11): 4493–501. doi:10.1021/ac9004309. PMID 19413330.
  • Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM (Aug 2009). "OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism". Journal of Molecular Medicine. 87 (8): 825–35. doi:10.1007/s00109-009-0490-z. PMC 2707950. PMID 19554302.
  • Chen T, Huang Z, Wang L, Wang Y, Wu F, Meng S, Wang C (Jul 2009). "MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages". Cardiovascular Research. 83 (1): 131–9. doi:10.1093/cvr/cvp121. PMID 19377067.
  • Wyles JP, Ridgway ND (Jul 2004). "VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus". Experimental Cell Research. 297 (2): 533–47. doi:10.1016/j.yexcr.2004.03.052. PMID 15212954.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Sowa ME, Bennett EJ, Gygi SP, Harper JW (Jul 2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
  • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (Nov 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
  • Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway ND, Huber M (Feb 2007). "Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation". Cellular Signalling. 19 (2): 384–92. doi:10.1016/j.cellsig.2006.07.009. PMID 16962287.
  • Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (Dec 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
  • Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (Aug 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
  • Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM (Nov 2010). "OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface". Experimental Cell Research. 316 (19): 3304–16. doi:10.1016/j.yexcr.2010.06.008. PMID 20599956.
  • Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (Oct 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.