OXR1

Protein-coding gene in the species Homo sapiens
OXR1
Identifiers
AliasesOXR1, TLDC3, Nbla00307, oxidation resistance 1, CHEGDD
External IDsOMIM: 605609; MGI: 2179326; HomoloGene: 24993; GeneCards: OXR1; OMA:OXR1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for OXR1
Genomic location for OXR1
Band8q23.1Start106,270,144 bp[1]
End106,752,694 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for OXR1
Genomic location for OXR1
Band15|15 B3.1Start41,310,878 bp[2]
End41,724,444 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • Achilles tendon

  • lateral nuclear group of thalamus

  • trigeminal ganglion

  • sperm

  • spinal ganglia

  • seminal vesicula

  • Brodmann area 23

  • corpus epididymis

  • prefrontal cortex
Top expressed in
  • medial dorsal nucleus

  • parotid gland

  • subiculum

  • pontine nuclei

  • primary motor cortex

  • habenula

  • medial geniculate nucleus

  • lobe of cerebellum

  • cerebellar vermis

  • inferior colliculus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • oxidoreductase activity
  • protein binding
  • molecular function
Cellular component
  • nucleolus
  • mitochondrion
  • cellular component
  • nucleoplasm
  • intracellular membrane-bounded organelle
Biological process
  • negative regulation of neuron apoptotic process
  • response to oxidative stress
  • cellular response to hydroperoxide
  • adult walking behavior
  • neuron apoptotic process
  • negative regulation of cellular response to oxidative stress
  • negative regulation of peptidyl-cysteine S-nitrosylation
  • negative regulation of oxidative stress-induced neuron death
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55074

170719

Ensembl

ENSG00000164830

ENSMUSG00000022307

UniProt

Q8N573

Q4KMM3

RefSeq (mRNA)
NM_001198532
NM_001198533
NM_001198534
NM_001198535
NM_018002

NM_181354

NM_001130163
NM_001130164
NM_001130165
NM_001130166
NM_130885

NM_001358976
NM_001358977
NM_001358978

RefSeq (protein)
NP_001185461
NP_001185462
NP_001185463
NP_001185464
NP_060472

NP_851999

NP_001123635
NP_001123636
NP_001123637
NP_001123638
NP_570955

NP_001345905
NP_001345906
NP_001345907

Location (UCSC)Chr 8: 106.27 – 106.75 MbChr 15: 41.31 – 41.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxidation resistance protein 1 is a protein that in humans is encoded by the OXR1 gene.[5][6] Loss of OXR1 function causes decline of the retromer complex.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022307 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Volkert MR, Elliott NA, Housman DE (Jan 2001). "Functional genomics reveals a family of eukaryotic oxidation protection genes". Proc Natl Acad Sci U S A. 97 (26): 14530–5. doi:10.1073/pnas.260495897. PMC 18953. PMID 11114193.
  6. ^ "Entrez Gene: OXR1 oxidation resistance 1".
  7. ^ Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications. 15 (1): 467. Bibcode:2024NatCo..15..467W. doi:10.1038/s41467-023-44343-3. PMC 10784588. PMID 38212606.

Further reading

  • Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
  • Durand M, Kolpak A, Farrell T, et al. (2007). "The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins". BMC Cell Biol. 8: 13. doi:10.1186/1471-2121-8-13. PMC 1847813. PMID 17391516.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Elliott NA, Volkert MR (2004). "Stress Induction and Mitochondrial Localization of Oxr1 Proteins in Yeast and Humans". Mol. Cell. Biol. 24 (8): 3180–7. doi:10.1128/MCB.24.8.3180-3187.2004. PMC 381681. PMID 15060142.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • v
  • t
  • e