PHLDB1

Protein-coding gene in the species Homo sapiens
PHLDB1
Identifiers
AliasesPHLDB1, LL5A, pleckstrin homology like domain family B member 1
External IDsOMIM: 612834; MGI: 2143230; HomoloGene: 15903; GeneCards: PHLDB1; OMA:PHLDB1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PHLDB1
Genomic location for PHLDB1
Band11q23.3Start118,606,440 bp[1]
End118,658,031 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PHLDB1
Genomic location for PHLDB1
Band9|9 A5.2Start44,686,304 bp[2]
End44,735,198 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • middle frontal gyrus

  • C1 segment

  • apex of heart

  • gastric mucosa

  • left uterine tube

  • canal of the cervix

  • corpus callosum

  • body of uterus

  • right auricle
Top expressed in
  • saccule

  • otic vesicle

  • Rostral migratory stream

  • ankle joint

  • motor neuron

  • otic placode

  • molar

  • external carotid artery

  • calvaria

  • lip
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23187

102693

Ensembl

ENSG00000019144

ENSMUSG00000048537

UniProt

Q86UU1

Q6PDH0

RefSeq (mRNA)

NM_001144758
NM_001144759
NM_015157

NM_153537

RefSeq (protein)

NP_001138230
NP_001138231
NP_055972
NP_001138231.1

NP_705765

Location (UCSC)Chr 11: 118.61 – 118.66 MbChr 9: 44.69 – 44.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.[5][6]

The first PHLDB1 cDNA was cloned from a rat pituitary cDNA library and named as LL5 after the clone number.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000019144 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048537 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (Oct 2003). "Identification and characterization of human LL5A gene and mouse Ll5a gene in silico". Int J Oncol. 23 (5): 1477–83. doi:10.3892/ijo.23.5.1477. PMID 14532993.
  6. ^ "Entrez Gene: PHLDB1 pleckstrin homology-like domain, family B, member 1".
  7. ^ Levi L, Hanukoglu I, Raikhinstein M, Kohen F, Koch Y (16 November 1993). "Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (2): 342–4. doi:10.1016/0167-4781(93)90171-9. PMID 8241284.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  • Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.