PHLDB2

Protein-coding gene in the species Homo sapiens
PHLDB2
Identifiers
AliasesPHLDB2, LL5b, LL5beta, pleckstrin homology like domain family B member 2
External IDsOMIM: 610298; MGI: 2444981; HomoloGene: 17100; GeneCards: PHLDB2; OMA:PHLDB2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PHLDB2
Genomic location for PHLDB2
Band3q13.2Start111,732,497 bp[1]
End111,976,517 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for PHLDB2
Genomic location for PHLDB2
Band16|16 B5Start45,566,606 bp[2]
End45,773,961 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • tail of epididymis

  • parietal pleura

  • placenta

  • Achilles tendon

  • decidua

  • right ventricle

  • cardiac muscle tissue of right atrium

  • tibial arteries

  • visceral pleura
Top expressed in
  • genital tubercle

  • renal corpuscle

  • left lung lobe

  • urothelium

  • gastrula

  • medullary collecting duct

  • tunica media of zone of aorta

  • transitional epithelium of urinary bladder

  • calvaria

  • Gonadal ridge
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • cadherin binding
Cellular component
  • plasma membrane
  • intermediate filament cytoskeleton
  • basal cortex
  • cell leading edge
  • membrane
  • focal adhesion
  • cytoplasm
  • cytosol
Biological process
  • negative regulation of wound healing, spreading of epidermal cells
  • regulation of epithelial to mesenchymal transition
  • regulation of microtubule cytoskeleton organization
  • positive regulation of basement membrane assembly involved in embryonic body morphogenesis
  • negative regulation of stress fiber assembly
  • regulation of gastrulation
  • microtubule cytoskeleton organization
  • negative regulation of focal adhesion assembly
  • establishment of protein localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90102

208177

Ensembl

ENSG00000144824

ENSMUSG00000033149

UniProt

Q86SQ0

Q8K1N2

RefSeq (mRNA)

NM_145753
NM_001134437
NM_001134438
NM_001134439

NM_001252442
NM_153412
NM_001357078

RefSeq (protein)

NP_001127909
NP_001127910
NP_001127911
NP_665696

NP_001239371
NP_700461
NP_001344007

Location (UCSC)Chr 3: 111.73 – 111.98 MbChr 16: 45.57 – 45.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.[5][6]

Interactions

PHLDB2 has been shown to interact with FLNC.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144824 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033149 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem. 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
  6. ^ "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Further reading

  • Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  • Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
  • Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.


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