PKIB

Protein-coding gene in the species Homo sapiens

PKIB
Identifiers
AliasesPKIB, PRKACN2, protein kinase (cAMP-dependent, catalytic) inhibitor beta, cAMP-dependent protein kinase inhibitor beta
External IDsOMIM: 606914; MGI: 101937; HomoloGene: 7474; GeneCards: PKIB; OMA:PKIB - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PKIB
Genomic location for PKIB
Band6q22.31Start122,471,917 bp[1]
End122,726,373 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for PKIB
Genomic location for PKIB
Band10 B4|10 29.22 cMStart57,508,077 bp[2]
End57,617,208 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • mucosa of ileum

  • mucosa of transverse colon

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • rectum

  • mucosa of sigmoid colon

  • placenta

  • bronchial epithelial cell

  • pons
Top expressed in
  • seminiferous tubule

  • spermatid

  • olfactory epithelium

  • lumbar spinal ganglion

  • lobe of cerebellum

  • cerebellar vermis

  • suprachiasmatic nucleus

  • supraoptic nucleus

  • carotid body

  • pontine nuclei
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein kinase inhibitor activity
  • cAMP-dependent protein kinase inhibitor activity
Cellular component
  • cytoplasm
  • nucleus
Biological process
  • positive regulation of telomere maintenance via telomerase
  • positive regulation of telomere capping
  • positive regulation of telomerase activity
  • negative regulation of cAMP-dependent protein kinase activity
  • negative regulation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5570

18768

Ensembl

ENSG00000135549

ENSMUSG00000019876

UniProt

Q9C010

Q04758

RefSeq (mRNA)
NM_001270393
NM_001270394
NM_001270395
NM_032471
NM_181794

NM_181795

NM_001039050
NM_001039051
NM_001039052
NM_001039053
NM_001190402

NM_008863

RefSeq (protein)
NP_001257322
NP_001257323
NP_001257324
NP_115860
NP_861459

NP_861460

n/a

Location (UCSC)Chr 6: 122.47 – 122.73 MbChr 10: 57.51 – 57.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.[5][6]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135549 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019876 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
  6. ^ a b "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor". Mol. Cell. Biol. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J. Neurooncol. 56 (3): 197–208. doi:10.1023/A:1015079705841. PMID 12061725. S2CID 23878825.
  • Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
  • Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse". J. Biol. Chem. 268 (15): 10927–31. doi:10.1016/S0021-9258(18)82074-9. PMID 7684369.
  • Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5383–7. Bibcode:1991PNAS...88.5383V. doi:10.1073/pnas.88.12.5383. PMC 51877. PMID 2052616.


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