PLEKHA1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/92/Protein_PLEKHA1_PDB_1eaz.png/250px-Protein_PLEKHA1_PDB_1eaz.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PLEKHA1, TAPP1, pleckstrin homology domain containing A1 |
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External IDs | OMIM: 607772; MGI: 2442213; HomoloGene: 11001; GeneCards: PLEKHA1; OMA:PLEKHA1 - orthologs |
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Gene location (Human) |
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![Chromosome 10 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png) | Chr. | Chromosome 10 (human)[1] |
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| Band | 10q26.13 | Start | 122,374,696 bp[1] |
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End | 122,442,602 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F3 | Start | 130,467,486 bp[2] |
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End | 130,515,042 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - skin of thigh
- sperm
- Brodmann area 23
- skin of hip
- middle temporal gyrus
- postcentral gyrus
- gingival epithelium
- synovial joint
- endothelial cell
- primary visual cortex
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| Top expressed in | - neural layer of retina
- decidua
- gastrula
- ciliary body
- olfactory bulb
- iris
- pineal gland
- CA3 field
- perirhinal cortex
- sciatic nerve
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/PBB_GE_PLEKHA1_219024_at_fs.png/250px-PBB_GE_PLEKHA1_219024_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - PDZ domain binding
- phosphatidylinositol-3,4-bisphosphate binding
- protein binding
- lipid binding
| Cellular component | - cytoplasm
- membrane
- nucleoplasm
- ruffle membrane
- extracellular exosome
- nucleus
- cytosol
- plasma membrane
| Biological process | - B cell receptor signaling pathway
- roof of mouth development
- negative regulation of protein kinase B signaling
- luteinization
- Leydig cell differentiation
- estrogen metabolic process
- androgen metabolic process
- ruffle organization
- multicellular organism growth
- establishment of protein localization
- skeletal system morphogenesis
- post-embryonic development
- female gonad development
- spermatogenesis
- phosphatidylinositol 3-kinase signaling
- platelet-derived growth factor receptor signaling pathway
- face morphogenesis
- cellular response to hydrogen peroxide
- phosphatidylinositol biosynthetic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001001974 NM_001195608 NM_021622 NM_001330178 |
| NM_133942 NM_001346515 NM_001357696 NM_001382373 NM_001382374
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NM_001382375 NM_001382376 NM_001382377 NM_001382378 NM_001382379 |
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RefSeq (protein) | NP_001001974 NP_001182537 NP_001317107 NP_067635 NP_001364159
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NP_001364160 NP_001364161 NP_001364163 NP_001364164 NP_001364166 NP_001364167 NP_001364169 NP_001364170 NP_001364171 NP_001364172 NP_001364173 NP_001364174 NP_001364175 NP_001364176 NP_001364177 NP_001364178 NP_001364179 NP_001364180 NP_001364181 NP_001364182 NP_001364183 NP_001364184 NP_001364185 NP_001364186 NP_001364187 |
| NP_001333444 NP_598703 NP_001344625 NP_001369302 NP_001369303
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NP_001369304 NP_001369305 NP_001369306 NP_001369307 NP_001369308 |
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Location (UCSC) | Chr 10: 122.37 – 122.44 Mb | Chr 7: 130.47 – 130.52 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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