PLEKHA5

Protein-coding gene in the species Homo sapiens

PLEKHA5
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2DKP

Identifiers
AliasesPLEKHA5, PEPP-2, PEPP2, pleckstrin homology domain containing A5
External IDsOMIM: 607770; MGI: 1923802; HomoloGene: 10377; GeneCards: PLEKHA5; OMA:PLEKHA5 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PLEKHA5
Genomic location for PLEKHA5
Band12p12.3Start19,129,752 bp[1]
End19,376,400 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PLEKHA5
Genomic location for PLEKHA5
Band6|6 G2Start140,369,780 bp[2]
End140,542,836 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of paranasal sinus

  • buccal mucosa cell

  • bronchial epithelial cell

  • endometrium

  • caput epididymis

  • renal medulla

  • corpus epididymis

  • right adrenal gland

  • tail of epididymis

  • left adrenal gland
Top expressed in
  • glossopharyngeal ganglion

  • spermatocyte

  • tail of embryo

  • neural layer of retina

  • superior frontal gyrus

  • zygote

  • olfactory tubercle

  • genital tubercle

  • cerebellar cortex

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-4-phosphate binding
  • phosphatidylinositol-5-phosphate binding
  • protein binding
  • phosphatidylinositol-3-phosphate binding
  • phosphatidylinositol-3,5-bisphosphate binding
Cellular component
  • membrane
  • nucleoplasm
  • cytoplasm
  • cytosol
  • postsynaptic density
  • glutamatergic synapse
Biological process
  • reproductive system development
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54477

109135

Ensembl

ENSG00000052126

ENSMUSG00000030231

UniProt

Q9HAU0

n/a

RefSeq (mRNA)

NM_001143821
NM_001190860
NM_001256470
NM_001256787
NM_019012

NM_144920

RefSeq (protein)
NP_001137293
NP_001177789
NP_001243399
NP_001243716
NP_061885

NP_001137293.2

n/a

Location (UCSC)Chr 12: 19.13 – 19.38 MbChr 6: 140.37 – 140.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000052126 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030231 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  6. ^ Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  7. ^ "Entrez Gene: PLEKHA5 pleckstrin homology domain containing, family A member 5".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Overview of all the structural information available in the PDB for UniProt: P00698 (Pleckstrin homology domain-containing family A member 5) at the PDBe-KB.
  • v
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  • 2dkp: Solution structure of the PH domain of pleckstrin homology domain-containing protein family A member 5 from human
    2dkp: Solution structure of the PH domain of pleckstrin homology domain-containing protein family A member 5 from human


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