PLEKHB2

Protein-coding gene in the species Homo sapiens
PLEKHB2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3AJ4, 3VIA

Identifiers
AliasesPLEKHB2, EVT2, pleckstrin homology domain containing B2
External IDsOMIM: 618452; MGI: 2385825; HomoloGene: 9938; GeneCards: PLEKHB2; OMA:PLEKHB2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PLEKHB2
Genomic location for PLEKHB2
Band2q21.1Start131,104,847 bp[1]
End131,353,709 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PLEKHB2
Genomic location for PLEKHB2
Band1|1 BStart34,889,057 bp[2]
End34,918,661 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • endothelial cell

  • superior vestibular nucleus

  • inferior ganglion of vagus nerve

  • Pars compacta

  • Brodmann area 23

  • cerebellar vermis

  • spinal ganglia

  • lateral nuclear group of thalamus

  • pars reticulata
Top expressed in
  • choroid plexus of fourth ventricle

  • medulla oblongata

  • superior colliculus

  • medial vestibular nucleus

  • entorhinal cortex

  • perirhinal cortex

  • neural layer of retina

  • pyloric antrum

  • dorsal tegmental nucleus

  • right kidney
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • phosphatidylinositol-3,4,5-trisphosphate binding
Cellular component
  • membrane
  • recycling endosome membrane
  • endosome
  • integral component of membrane
Biological process
  • regulation of cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55041

226971

Ensembl

ENSG00000115762

ENSMUSG00000026123

UniProt

Q96CS7

Q9QZC7

RefSeq (mRNA)
NM_001031706
NM_001100623
NM_001267062
NM_001267063
NM_001267064

NM_001267065
NM_001267066
NM_001267067
NM_001267068
NM_001309448
NM_001309450
NM_001309451
NM_001309452
NM_017958

NM_145516
NM_175421
NM_001357425

RefSeq (protein)
NP_001094093
NP_001253991
NP_001253992
NP_001253993
NP_001253994

NP_001253995
NP_001253996
NP_001253997
NP_001296377
NP_001296379
NP_001296380
NP_001296381
NP_060428
NP_001094093.1

NP_663491
NP_780630
NP_001344354

Location (UCSC)Chr 2: 131.1 – 131.35 MbChr 1: 34.89 – 34.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115762 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026123 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. Bibcode:1999PNAS...96.4633K. doi:10.1073/pnas.96.8.4633. PMC 16384. PMID 10200314.
  6. ^ "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
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  • 2dhi: Solution structure of the PH domain of Evectin-2 from mouse
    2dhi: Solution structure of the PH domain of Evectin-2 from mouse


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