PLEKHF2

Protein-coding gene in the species Homo sapiens
PLEKHF2
Identifiers
AliasesPLEKHF2, EAPF, PHAFIN2, ZFYVE18, pleckstrin homology and FYVE domain containing 2
External IDsOMIM: 615208; MGI: 1919051; HomoloGene: 11620; GeneCards: PLEKHF2; OMA:PLEKHF2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for PLEKHF2
Genomic location for PLEKHF2
Band8q22.1Start95,133,785 bp[1]
End95,156,685 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PLEKHF2
Genomic location for PLEKHF2
Band4|4 A1Start10,988,662 bp[2]
End11,007,927 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • skin of thigh

  • palpebral conjunctiva

  • bronchial epithelial cell

  • skin of hip

  • monocyte

  • sperm

  • bone marrow

  • corpus epididymis

  • olfactory zone of nasal mucosa
Top expressed in
  • granulocyte

  • right kidney

  • neural layer of retina

  • yolk sac

  • spermatocyte

  • morula

  • proximal tubule

  • endocardial cushion

  • lip

  • atrioventricular valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • phosphatidylinositol binding
Cellular component
  • endosome
  • early endosome membrane
  • transport vesicle
  • endoplasmic reticulum
  • membrane
Biological process
  • protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79666

71801

Ensembl

ENSG00000175895

ENSMUSG00000049969

UniProt

Q9H8W4

Q91WB4

RefSeq (mRNA)

NM_024613

NM_175175

RefSeq (protein)

NP_078889

NP_780384

Location (UCSC)Chr 8: 95.13 – 95.16 MbChr 4: 10.99 – 11.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the PLEKHF2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175895 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049969 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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