PLSCR2

Protein-coding gene in the species Homo sapiens
PLSCR2
Identifiers
AliasesPLSCR2, phospholipid scramblase 2
External IDsOMIM: 607610; HomoloGene: 124471; GeneCards: PLSCR2; OMA:PLSCR2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PLSCR2
Genomic location for PLSCR2
Band3q24Start146,391,421 bp[1]
End146,495,991 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • testicle

  • left testis

  • right testis

  • granulocyte

  • monocyte

  • islet of Langerhans

  • body of pancreas

  • gallbladder

  • rectum
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phospholipid scramblase activity
  • calcium ion binding
  • metal ion binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • nucleus
Biological process
  • plasma membrane phospholipid scrambling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57047

n/a

Ensembl

ENSG00000163746

n/a

UniProt

Q9NRY7

n/a

RefSeq (mRNA)

NM_001199978
NM_001199979
NM_020359

n/a

RefSeq (protein)

NP_001186907
NP_001186908
NP_065092

n/a

Location (UCSC)Chr 3: 146.39 – 146.5 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Phospholipid scramblase 2, also known as Ca2+-dependent phospholipid scramblase 2, is a protein that in humans is encoded by the PLSCR2 gene.[3][4]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163746 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: phospholipid scramblase 2".
  4. ^ Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sahu SK, Aradhyam GK, Gummadi SN (2009). "Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell". Biochim. Biophys. Acta. 1790 (10): 1274–81. doi:10.1016/j.bbagen.2009.06.008. PMID 19540310.
  • Yu A, McMaster CR, Byers DM, et al. (2003). "Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1". J. Biol. Chem. 278 (11): 9706–14. doi:10.1074/jbc.M204614200. PMID 12509439.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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