PLXND1

Protein-coding gene in the species Homo sapiens
PLXND1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3H6N

Identifiers
AliasesPLXND1, PLEXD1, plexin D1
External IDsOMIM: 604282; MGI: 2154244; HomoloGene: 22866; GeneCards: PLXND1; OMA:PLXND1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PLXND1
Genomic location for PLXND1
Band3q22.1Start129,555,214 bp[1]
End129,606,676 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PLXND1
Genomic location for PLXND1
Band6|6 E3Start115,931,772 bp[2]
End115,971,966 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • upper lobe of left lung

  • right coronary artery

  • right lung

  • tibial nerve

  • canal of the cervix

  • apex of heart

  • body of uterus

  • left uterine tube

  • gallbladder

  • left coronary artery
Top expressed in
  • thymus

  • external carotid artery

  • ankle joint

  • molar

  • lumbar spinal ganglion

  • internal carotid artery

  • yolk sac

  • atrium

  • genital tubercle

  • decidua
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein domain specific binding
  • protein binding
  • semaphorin receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • lamellipodium
  • integral component of plasma membrane
  • lamellipodium membrane
  • cell projection
  • semaphorin receptor complex
Biological process
  • cardiac septum development
  • outflow tract morphogenesis
  • regulation of angiogenesis
  • coronary vasculature development
  • multicellular organism development
  • aorta development
  • angiogenesis
  • dichotomous subdivision of terminal units involved in salivary gland branching
  • branching involved in blood vessel morphogenesis
  • synapse assembly
  • positive regulation of protein binding
  • endothelial cell migration
  • semaphorin-plexin signaling pathway
  • signal transduction
  • negative regulation of cell adhesion
  • regulation of cell shape
  • regulation of cell migration
  • positive regulation of axonogenesis
  • regulation of GTPase activity
  • positive regulation of transcription of Notch receptor target
  • semaphorin-plexin signaling pathway involved in axon guidance
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23129

67784

Ensembl

ENSG00000004399

ENSMUSG00000030123

UniProt

Q9Y4D7

Q3UH93

RefSeq (mRNA)

NM_015103

NM_026376

RefSeq (protein)

NP_055918

NP_080652

Location (UCSC)Chr 3: 129.56 – 129.61 MbChr 6: 115.93 – 115.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004399 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030123 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn. 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018. S2CID 36110289.
  6. ^ "Entrez Gene: PLXND1 plexin D1".

Further reading

  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" (PDF). DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gitler AD, Lu MM, Epstein JA (2004). "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development". Dev. Cell. 7 (1): 107–16. doi:10.1016/j.devcel.2004.06.002. PMID 15239958.
  • van der Zwaag B, Verzijl HT, Wichers KH, et al. (2004). "Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients". Pediatr. Neurol. 31 (2): 114–8. doi:10.1016/j.pediatrneurol.2004.02.004. PMID 15301830.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.


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