POLE4

Protein-coding gene in the species Homo sapiens
POLE4
Identifiers
AliasesPOLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDsOMIM: 607269; MGI: 1914229; HomoloGene: 41339; GeneCards: POLE4; OMA:POLE4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for POLE4
Genomic location for POLE4
Band2p12Start74,958,643 bp[1]
End74,970,128 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for POLE4
Genomic location for POLE4
Band6|6 C3Start82,595,973 bp[2]
End82,682,346 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • cingulate gyrus

  • anterior cingulate cortex

  • mucosa of transverse colon

  • right adrenal cortex

  • popliteal artery

  • tibial arteries

  • monocyte

  • left adrenal gland

  • gastrocnemius muscle
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • yolk sac

  • retinal pigment epithelium

  • ciliary body

  • right kidney

  • ventricular zone

  • embryo

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • protein binding
  • protein heterodimerization activity
Cellular component
  • epsilon DNA polymerase complex
  • nucleus
  • nucleoplasm
Biological process
  • histone H3 acetylation
  • DNA biosynthetic process
  • G1/S transition of mitotic cell cycle
  • DNA replication initiation
  • telomere maintenance via semi-conservative replication
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56655

66979

Ensembl

ENSG00000115350

ENSMUSG00000030042

UniProt

Q9NR33

Q9CQ36

RefSeq (mRNA)

NM_019896

NM_025882
NM_001370295

RefSeq (protein)

NP_063949

NP_080158
NP_001357224

Location (UCSC)Chr 2: 74.96 – 74.97 MbChr 6: 82.6 – 82.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115350 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030042 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

Further reading

  • Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
  • Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
  • Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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Initiation
Prokaryotic
(initiation)
Eukaryotic
(preparation in
G1 phase)
Both
Replication
Prokaryotic
(elongation)
Eukaryotic
(synthesis in
S phase)
Both
Termination


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