POLR3E

Protein-coding gene in the species Homo sapiens
POLR3E
Identifiers
AliasesPOLR3E, RPC5, SIN, polymerase (RNA) III subunit E, RNA polymerase III subunit E, C37
External IDsOMIM: 617815; MGI: 1349452; HomoloGene: 14052; GeneCards: POLR3E; OMA:POLR3E - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for POLR3E
Genomic location for POLR3E
Band16p12.2Start22,297,375 bp[1]
End22,335,101 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for POLR3E
Genomic location for POLR3E
Band7|7 F2Start120,516,967 bp[2]
End120,546,655 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • muscle of thigh

  • body of pancreas

  • left lobe of thyroid gland

  • anterior pituitary

  • right lobe of thyroid gland

  • skin of leg

  • skin of abdomen

  • right uterine tube

  • left ovary
Top expressed in
  • right kidney

  • proximal tubule

  • human kidney

  • epiblast

  • hair follicle

  • seminiferous tubule

  • endothelial cell of lymphatic vessel

  • condyle

  • yolk sac

  • Paneth cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-directed 5'-3' RNA polymerase activity
  • RNA polymerase III activity
Cellular component
  • RNA polymerase III complex
  • cytosol
  • nucleus
  • nucleoplasm
Biological process
  • immune system process
  • defense response to virus
  • transcription, DNA-templated
  • transcription by RNA polymerase III
  • innate immune response
  • positive regulation of type I interferon production
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55718

26939

Ensembl

ENSG00000284282
ENSG00000058600

ENSMUSG00000030880

UniProt

Q9NVU0

Q9CZT4

RefSeq (mRNA)

NM_001258033
NM_001258034
NM_001258035
NM_001258036
NM_018119

NM_001164096
NM_025298
NM_001379288

RefSeq (protein)

NP_001244962
NP_001244963
NP_001244964
NP_001244965
NP_060589

NP_001157568
NP_079574
NP_001366217

Location (UCSC)Chr 16: 22.3 – 22.34 MbChr 7: 120.52 – 120.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.[5][6][7]

Interactions

POLR3E has been shown to interact with POLR3D.[8]

Notes and references

  1. ^ a b c ENSG00000058600 GRCh38: Ensembl release 89: ENSG00000284282, ENSG00000058600 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030880 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ Dong Z, Bell LR (Nov 1999). "SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal". Gene. 237 (2): 421–428. doi:10.1016/S0378-1119(99)00303-0. PMID 10521666.
  7. ^ "Entrez Gene: POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)".
  8. ^ Hu, Ping; Wu Si; Sun Yuling; Yuan Chih-Chi; Kobayashi Ryuji; Myers Michael P; Nouria Hernandez (Nov 2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22). United States: 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. ISSN 0270-7306. PMC 134740. PMID 12391170.

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–1147. PMID 1403646.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits". Mol. Cell. Biol. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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